Uracil derivatives as HIV-1 capsid protein inhibitors: design, in silico, in vitro and cytotoxicity studies
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DOI: 10.1039/d2ra02450k
Abstract: A series of novel uracil derivatives such as bispyrimidine dione and tetrapyrimidine dione derivatives were designed based on the existing four-point pharmacophore model as effective HIV capsid protein inhibitors. The compounds were initially docked with… read more here.
Keywords: hiv capsid; capsid protein; uracil derivatives; protein inhibitors ... See more keywords
Structure-affinity and structure-residence time relationships of macrocyclic Gαq protein inhibitors.
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DOI: 10.2139/ssrn.4310437
Abstract: The macrocyclic depsipeptides YM-254890 (YM) and FR900359 (FR) are potent inhibitors of Gαq/11 proteins. They are important pharmacological tools and have potential as therapeutic drugs. The hydrogenated, tritium-labeled YM and FR derivatives display largely different… read more here.
Keywords: protein inhibitors; structure; structure affinity; residence ... See more keywords