Protein interactome of the deamidase phosphoribosylformylglycinamidine synthetase (PFAS) by LC-MS/MS.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2019.04.039
Abstract: Phosphoribosylformylglycinamidine synthase (PFAS) is an essential enzyme in de novo synthesis of purine. Previously, PFAS has been reported to modulate RIG-I activation during viral infection via deamidation. In this study, we sought to identify potential… read more here.
Keywords: protein interactome; cct2 prdx1; pfas; cad cct2 ... See more keywords
Analysis of aging-related protein interactome and cross-network module comparisons across tissues provide new insights into aging
Sign Up to like & getrecommendations! Published in 2021 at "Computational biology and chemistry"
DOI: 10.1016/j.compbiolchem.2021.107506
Abstract: Delaying the human aging process and thus eliminating the risk factors for age-related diseases is one of the prime objectives. While various aging-associated genes and proteins have been characterized, which provide a significant understanding of… read more here.
Keywords: network; protein interactome; analysis; cross network ... See more keywords
Bifunctional Lipid-Derived Affinity-Based Probes (AfBPs) for Analysis of Lipid-Protein Interactome.
Sign Up to like & getrecommendations! Published in 2022 at "Accounts of chemical research"
DOI: 10.1021/acs.accounts.2c00593
Abstract: ConspectusAlthough lipids are not genetically encoded, they are fundamental building blocks of cell membranes and essential components of cell metabolites. Lipids regulate various biological processes, including energy storage, membrane trafficking, signal transduction, and protein secretion;… read more here.
Keywords: derived affinity; lipid protein; lipid derived; protein interactome ... See more keywords
Putative Protein Interactome of the Rhomboid Protease RHBDL4.
Sign Up to like & getrecommendations! Published in 2023 at "Biochemistry"
DOI: 10.1021/acs.biochem.2c00680
Abstract: The physiological functions of the rhomboid-related protein 4 (RHBDL4) are emerging, but their molecular details remain unclear. Because increased expression of RHBDL4 has been clinically linked to poorer outcomes in cancer patients, this association urgently… read more here.
Keywords: rhomboid protease; rhbdl4; interactome rhomboid; protein ... See more keywords
A Protein Interactome-Based Framework Reveals the General Toxicity of Chemicals.
Sign Up to like & getrecommendations! Published in 2025 at "Environmental science & technology"
DOI: 10.1021/acs.est.5c08341
Abstract: Humans are exposed to various chemicals, and understanding their toxicity is essential for safeguarding their health. However, current toxicological methods often focus on specific diseases or chemicals, missing broader patterns of toxicity. Here, we propose… read more here.
Keywords: based framework; chemical disease; protein interactome; toxicity ... See more keywords
Potentially repurposable drugs for schizophrenia identified from its interactome
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-48307-w
Abstract: We previously presented the protein-protein interaction network of schizophrenia associated genes, and from it, the drug-protein interactome which showed the drugs that target any of the proteins in the interactome. Here, we studied these drugs… read more here.
Keywords: schizophrenia; protein interactome; drug; expression ... See more keywords
Pan-cancer mapping of differential protein-protein interactions
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-60127-x
Abstract: Deciphering the variations in the protein interactome is required to reach a systems-level understanding of tumorigenesis. To accomplish this task, we have considered the clinical and transcriptome data on >6000 samples from The Cancer Genome… read more here.
Keywords: protein; protein interactome; protein interactions; protein protein ... See more keywords
The proximity-based protein interactome and regulatory logics of the transcription factor p65 NF-κB/RELA
Sign Up to like & getrecommendations! Published in 2025 at "EMBO Reports"
DOI: 10.1038/s44319-024-00339-8
Abstract: The protein interactome of p65/RELA, the most active subunit of the transcription factor (TF) NF-κB, has not been previously determined in living cells. Using p65-miniTurbo fusion proteins and biotin tagging, we identify >350 RELA interactors… read more here.
Keywords: rela; transcription factor; protein interactome; gene ... See more keywords
Protein Interactome Profiling of Stable Molecular Complexes in Biomaterial Lysate
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms232415697
Abstract: Most proteins function as part of various complexes, forming via stable and dynamic protein–protein interactions (PPIs). The profiling of PPIs expands the fundamental knowledge about the structures, functions, and regulation patterns of protein complexes and… read more here.
Keywords: profiling stable; interactome profiling; molecular complexes; stable molecular ... See more keywords
Protein Interactome of Amyloid-β as a Therapeutic Target
Sign Up to like & getrecommendations! Published in 2023 at "Pharmaceuticals"
DOI: 10.3390/ph16020312
Abstract: The amyloid concept of Alzheimer’s disease (AD) assumes the β-amyloid peptide (Aβ) as the main pathogenic factor, which injures neural and other brain cells, causing their malfunction and death. Although Aβ has been documented to… read more here.
Keywords: interactome amyloid; protein interactome; amyloid therapeutic; therapeutic target ... See more keywords
The Protein Interactome of Glycolysis in Escherichia coli
Sign Up to like & getrecommendations! Published in 2021 at "Proteomes"
DOI: 10.3390/proteomes9020016
Abstract: Glycolysis is regulated by numerous mechanisms including allosteric regulation, post-translational modification or protein-protein interactions (PPI). While glycolytic enzymes have been found to interact with hundreds of proteins, the impact of only some of these PPIs… read more here.
Keywords: protein; protein interactome; glycolysis; glycolysis escherichia ... See more keywords