Identifying and Validating MYC:Protein Interactors in Pursuit of Novel Anti-MYC Therapies.
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DOI: 10.1007/978-1-0716-1476-1_4
Abstract: By identifying MYC protein-protein interactors, we aim to gain a deeper mechanistic understanding of MYC as a regulator of gene transcription and potent oncoprotein. This information can then be used to devise strategies for disrupting… read more here.
Keywords: protein; identifying validating; myc protein; protein interactors ... See more keywords
RNA and Protein Interactors with TDP-43 in Human Spinal-Cord Lysates in Amyotrophic Lateral Sclerosis.
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DOI: 10.1021/acs.jproteome.8b00126
Abstract: The TAR DNA-binding protein of 43 kDa (TDP-43) is a dual function RNA- and DNA-binding protein with varied cellular functions. In degenerating motor neurons in amyotrophic lateral sclerosis (ALS), TDP-43 relocalizes from the nucleus to… read more here.
Keywords: protein; protein interactors; rna; interactors tdp ... See more keywords
Chemical proteomic profiling reveals protein interactors of the alarmones diadenosine triphosphate and tetraphosphate
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DOI: 10.1038/s41467-021-26075-4
Abstract: The nucleotides diadenosine triphosphate (Ap3A) and diadenosine tetraphosphate (Ap4A) are formed in prokaryotic and eukaryotic cells. Since their concentrations increase significantly upon cellular stress, they are considered to be alarmones triggering stress adaptive processes. However,… read more here.
Keywords: profiling reveals; protein interactors; reveals protein; proteomic profiling ... See more keywords