Protein interface redesign facilitates the transformation of nanocage building blocks to 1D and 2D nanomaterials
Sign Up to like & getrecommendations! Published in 2021 at "Nature Communications"
DOI: 10.1038/s41467-021-25199-x
Abstract: Although various artificial protein nanoarchitectures have been constructed, controlling the transformation between different protein assemblies has largely been unexplored. Here, we describe an approach to realize the self-assembly transformation of dimeric building blocks by adjusting… read more here.
Keywords: building blocks; protein interface; nanocage; interface redesign ... See more keywords
PIPENN-EMB ensemble net and protein embeddings generalise protein interface prediction beyond homology
Sign Up to like & getrecommendations! Published in 2025 at "Scientific Reports"
DOI: 10.1038/s41598-025-88445-y
Abstract: Protein interactions are crucial for understanding biological functions and disease mechanisms, but predicting these remains a complex task in computational biology. Increasingly, Deep Learning models are having success in interface prediction. This study presents PIPENN-EMB… read more here.
Keywords: protein interface; protein; interface prediction; pipenn emb ... See more keywords
PIPENN: protein interface prediction from sequence with an ensemble of neural nets
Sign Up to like & getrecommendations! Published in 2022 at "Bioinformatics"
DOI: 10.1093/bioinformatics/btac071
Abstract: Abstract Motivation The interactions between proteins and other molecules are essential to many biological and cellular processes. Experimental identification of interface residues is a time-consuming, costly and challenging task, while protein sequence data are ubiquitous.… read more here.
Keywords: protein protein; sequence; protein interface; prediction ... See more keywords
Patch-DCA: improved protein interface prediction by utilizing structural information and clustering DCA scores
Sign Up to like & getrecommendations! Published in 2020 at "Bioinformatics"
DOI: 10.1093/bioinformatics/btz791
Abstract: MOTIVATION Over the past decade there have been impressive advances in determining the 3D structures of protein complexes. However, there are still many complexes with unknown structures, even when the structures of the individual proteins… read more here.
Keywords: protein interface; information; interface prediction; dca ... See more keywords
Identifying protein-protein interface via a novel multi-scale local sequence and structural representation
Sign Up to like & getrecommendations! Published in 2019 at "BMC Bioinformatics"
DOI: 10.1186/s12859-019-3048-2
Abstract: Protein-protein interaction plays a key role in a multitude of biological processes, such as signal transduction, de novo drug design, immune responses, and enzymatic activities. Gaining insights of various binding abilities can deepen our understanding… read more here.
Keywords: protein; protein interface; protein protein; identifying protein ... See more keywords
Elaiophylin Is a Potent Hsp90/ Cdc37 Protein Interface Inhibitor with K-Ras Nanocluster Selectivity
Sign Up to like & getrecommendations! Published in 2021 at "Biomolecules"
DOI: 10.3390/biom11060836
Abstract: The natural product elaiophylin is a macrodiolide with a broad range of biological activities. However, no direct target of elaiophylin in eukaryotes has been described so far, which hinders a systematic explanation of its astonishing… read more here.
Keywords: interface inhibitor; protein interface; hsp90; hsp90 cdc37 ... See more keywords