Structural motifs in protein cores and at protein–protein interfaces are different
Sign Up to like & getrecommendations! Published in 2020 at "Protein Science"
DOI: 10.1002/pro.3996
Abstract: Structures of proteins and protein–protein complexes are determined by the same physical principles and thus share a number of similarities. At the same time, there could be differences because in order to function, proteins interact… read more here.
Keywords: protein; structural motifs; protein interfaces; protein protein ... See more keywords
Methods for Discovering and Targeting Druggable Protein-Protein Interfaces and Their Application to Repurposing.
Sign Up to like & getrecommendations! Published in 2019 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-8955-3_1
Abstract: Drug repurposing is a creative and resourceful approach to increase the number of therapies by exploiting available and approved drugs. However, identifying new protein targets for previously approved drugs is challenging. Although new strategies have… read more here.
Keywords: protein; drug repurposing; protein interfaces; drug ... See more keywords
Residue-Specific Insights into the Intermolecular Protein-Protein Interfaces Driving Amelogenin Self-Assembly in Solution.
Sign Up to like & getrecommendations! Published in 2022 at "Biochemistry"
DOI: 10.1021/acs.biochem.2c00522
Abstract: Amelogenin, the dominant organic component (>90%) in the early stages of amelogenesis, orchestrates the mineralization of apatite crystals into enamel. The self-association properties of amelogenin as a function of pH and protein concentration have been… read more here.
Keywords: protein protein; self assembly; amelogenin; protein interfaces ... See more keywords
Database-Driven Identification of Structurally Similar Protein-Protein Interfaces
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Chemical Information and Modeling"
DOI: 10.1021/acs.jcim.3c01462
Abstract: Analyzing the similarity of protein interfaces in protein-protein interactions gives new insights into protein function and assists in discovering new drugs. Usually, tools that assess the similarity focus on the interactions between two protein interfaces,… read more here.
Keywords: database driven; protein; protein protein; protein interfaces ... See more keywords
Targeting Unoccupied Surfaces on Protein-Protein Interfaces.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.7b05960
Abstract: The use of peptidomimetic scaffolds to target protein-protein interfaces is a promising strategy for inhibitor design. The strategy relies on mimicry of protein motifs that exhibit a concentration of native hot spot residues. To address… read more here.
Keywords: unoccupied surfaces; protein interfaces; protein protein; targeting unoccupied ... See more keywords
Conformational diversity and protein–protein interfaces in drug repurposing in Ras signaling pathway
Sign Up to like & getrecommendations! Published in 2024 at "Scientific Reports"
DOI: 10.1038/s41598-023-50913-8
Abstract: We focus on drug repurposing in the Ras signaling pathway, considering structural similarities of protein–protein interfaces. The interfaces formed by physically interacting proteins are found from PDB if available and via PRISM (PRotein Interaction by… read more here.
Keywords: drug repurposing; repurposing ras; protein; protein protein ... See more keywords
EuDockScore: Euclidean graph neural networks for scoring protein–protein interfaces
Sign Up to like & getrecommendations! Published in 2024 at "Bioinformatics"
DOI: 10.1101/2024.06.04.597410
Abstract: Protein-protein interactions are essential for a variety of biological phenomena including mediating bio-chemical reactions, cell signaling, and the immune response. Proteins seek to form interfaces which reduce overall system energy. Although determination of single polypeptide… read more here.
Keywords: graph neural; protein; protein protein; euclidean graph ... See more keywords
Targeting Protein–Protein Interfaces with Peptides: The Contribution of Chemical Combinatorial Peptide Library Approaches
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24097842
Abstract: Protein–protein interfaces play fundamental roles in the molecular mechanisms underlying pathophysiological pathways and are important targets for the design of compounds of therapeutic interest. However, the identification of binding sites on protein surfaces and the… read more here.
Keywords: protein protein; methodology; peptide; chemical ... See more keywords