Targeting the messengers: Serine/threonine protein kinases as potential targets for antimycobacterial drug development
Sign Up to like & getrecommendations! Published in 2018 at "IUBMB Life"
DOI: 10.1002/iub.1871
Abstract: The emergence of increasingly drug‐resistant Mycobacterium tuberculosis strains has become a crucial public health concern. In order to effectively treat tuberculosis, it is imperative to find newer drug targets, which are important for the in… read more here.
Keywords: serine threonine; protein kinases; drug; tuberculosis ... See more keywords
Multi‐omics analysis reveals expression complexity and functional diversity of mouse kinome
Sign Up to like & getrecommendations! Published in 2022 at "PROTEOMICS"
DOI: 10.1002/pmic.202200120
Abstract: Protein kinases are a crucial component of signaling pathways involved in a wide range of cellular responses, including growth, proliferation, differentiation, and migration. Systematic investigation of protein kinases is critical to better understand phosphorylation‐mediated signaling… read more here.
Keywords: multi omics; protein kinases; c57bl; analysis ... See more keywords
Nanopore Enzymology to Study Protein Kinases and Their Inhibition by Small Molecules.
Sign Up to like & getrecommendations! Published in 2021 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-0806-7_8
Abstract: Nanopore enzymology is a powerful single-molecule technique for the label-free study of enzymes using engineered protein nanopore sensors. The technique has been applied to protein kinases, where it has enabled the full repertoire of kinase… read more here.
Keywords: protein; inhibition; protein kinases; study ... See more keywords
Production of Protein Kinases in E. coli.
Sign Up to like & getrecommendations! Published in 2017 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-6887-9_16
Abstract: Recombinant protein expression is widely used to generate milligram quantities of protein kinases for crystallographic, enzymatic, or other biophysical assays in vitro. Expression in E. coli is fast, cheap, and reliable. Here I present a… read more here.
Keywords: protein; protein kinases; expression; production protein ... See more keywords
Regulation of Multifunctional Calcium/Calmodulin Stimulated Protein Kinases by Molecular Targeting.
Sign Up to like & getrecommendations! Published in 2020 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-3-030-12457-1_26
Abstract: Multifunctional calcium/calmodulin-stimulated protein kinases control a broad range of cellular functions in a multitude of cell types. This family of kinases contain several structural similarities and all are regulated by phosphorylation, which either activates, inhibits… read more here.
Keywords: multifunctional calcium; protein kinases; calmodulin stimulated; molecular targeting ... See more keywords
Protein Kinases in Hematological Disorders.
Sign Up to like & getrecommendations! Published in 2021 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-3-030-49844-3_15
Abstract: Cell signaling is an important part of the complex system of molecular communication that governs basic cellular activities and coordinates cell cycle machinery. Pathological alterations in the cellular information processing may be responsible for the… read more here.
Keywords: kinase; protein kinases; local ras; hematological disorders ... See more keywords
Signal Transduction in Immune Cells and Protein Kinases.
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DOI: 10.1007/978-3-030-49844-3_5
Abstract: Immune response relies upon several intracellular signaling events. Among the protein kinases involved in these pathways, members of the protein kinase C (PKC) family are prominent molecules because they have the capacity to acutely and… read more here.
Keywords: immune; signal transduction; protein kinases; transduction immune ... See more keywords
Bile Acid Toxicity and Protein Kinases.
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DOI: 10.1007/978-3-030-49844-3_9
Abstract: If the bile acids reach to pathological concentrations due to cholestasis, accumulation of hydrophobic bile acids within the hepatocyte may result in cell death. Thus, hydrophobic bile acids induce apoptosis in hepatocytes, while hydrophilic bile… read more here.
Keywords: bile acids; death; apoptosis; hydrophobic bile ... See more keywords
The Rio1 protein kinases/ATPases: conserved regulators of growth, division, and genomic stability
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DOI: 10.1007/s00294-018-0912-y
Abstract: The atypical Rio1 protein kinases/ATPases, which exist in most archaea and eukaryotes, have been studied intensely to understand how they promote small ribosomal subunit (SSU) maturation. However, mutant and knockdown phenotypes in various organisms suggested… read more here.
Keywords: kinases atpases; division; protein kinases; growth division ... See more keywords
Targeting malaria protein kinases.
Sign Up to like & getrecommendations! Published in 2021 at "Advances in protein chemistry and structural biology"
DOI: 10.1016/bs.apcsb.2020.10.004
Abstract: Malaria is one of the most impacting public health problems in tropical and subtropical areas of the globe, with approximately 200 million cases worldwide annually. In the absence of an effective vaccine, rapid treatment is… read more here.
Keywords: new antimalarial; protein kinases; malaria protein; biology ... See more keywords
Targeting the immunity protein kinases for immuno-oncology.
Sign Up to like & getrecommendations! Published in 2019 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2018.11.072
Abstract: With the rise of immuno-oncology, small-molecule modulators targeting immune system and inflammatory processes are becoming a research hotspot. This work mainly focuses on key kinases acting as central nodes in immune signaling pathways. Although over… read more here.
Keywords: immunity protein; oncology; protein kinases; immuno oncology ... See more keywords