Protein S-Leu17Pro disrupts the hydrophobicity of its signal peptide causing a proteasome-dependent degradation.
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DOI: 10.1016/j.thromres.2021.12.014
Abstract: INTRODUCTION Protein S is a vitamin K-dependent glycoprotein with important anticoagulant, fibrinolytic, anti-inflammatory, anti-apoptotic, and cytoprotective functions. Congenital protein S deficiency is an autosomal dominant thrombophilia due to protein S gene (PROS1) variations. Our group… read more here.
Keywords: signal peptide; recombinant protein; protein deficiency; protein ... See more keywords