Association of Klotho Protein Levels and KL-VS Heterozygosity With Alzheimer Disease and Amyloid and Tau Burden
Sign Up to like & getrecommendations! Published in 2022 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2022.43232
Abstract: Key Points Question What is the association between Klotho protein levels in cerebrospinal fluid (CSF) and plasma, heterozygosity status of the KL-VS haplotype, and amyloid and tau burden among cognitively healthy controls and patients with… read more here.
Keywords: amyloid tau; heterozygosity; protein levels; klotho protein ... See more keywords
Protein interaction screening identifies SH3RF1 as a new regulator of FAT1 protein levels
Sign Up to like & getrecommendations! Published in 2017 at "FEBS Letters"
DOI: 10.1002/1873-3468.12569
Abstract: Mutations and ectopic FAT1 cadherin expression are implicated in a broad spectrum of diseases ranging from developmental disorders to cancer. The regulation of FAT1 and its downstream signalling pathways remain incompletely understood. We hypothesized that… read more here.
Keywords: regulator fat1; fat1; protein levels; fat1 protein ... See more keywords
C‐reactive protein levels in patients with amyotrophic lateral sclerosis: A systematic review
Sign Up to like & getrecommendations! Published in 2022 at "Brain and Behavior"
DOI: 10.1002/brb3.2532
Abstract: Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease affecting cortical and spinal motor neurons. There is a lack of optimal biomarkers to diagnose and prognosticate the ALS patients. C‐reactive protein (CRP), an inflammatory marker,… read more here.
Keywords: reactive protein; lateral sclerosis; levels patients; protein levels ... See more keywords
Validation of absolutely quantitated Ki67 and cyclinD1 protein levels for prognosis of Luminal‐like breast cancer patients
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Clinical Laboratory Analysis"
DOI: 10.1002/jcla.24601
Abstract: To translate a clinical research finding into daily clinical practice requires well‐controlled clinical trials. We have demonstrated the usage of absolute quantitation of Ki67 and cyclinD1 protein levels to improve prognosis of Luminal‐like patients based… read more here.
Keywords: luminal like; breast cancer; prognosis luminal; protein levels ... See more keywords
Spinocerebellar Ataxia Type 1: Molecular Mechanisms of Neurodegeneration and Preclinical Studies.
Sign Up to like & getrecommendations! Published in 2018 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-3-319-71779-1_6
Abstract: Spinocerebellar ataxia type 1 (SCA1) is an adult-onset, inherited disease that leads to degeneration of Purkinje cells of the cerebellum and culminates in death 10-30 years after disease onset. SCA1 is caused by a CAG repeat… read more here.
Keywords: protein; ataxia type; spinocerebellar ataxia; preclinical studies ... See more keywords
Specific Increase of Protein Levels by Enhancing Translation Using Antisense Oligonucleotides Targeting Upstream Open Frames.
Sign Up to like & getrecommendations! Published in 2017 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-981-10-4310-9_9
Abstract: A number of diseases are caused by low levels of key proteins; therefore, increasing the amount of specific proteins in human bodies is of therapeutic interest. Protein expression is downregulated by some structural or sequence… read more here.
Keywords: protein; increase; translation; protein levels ... See more keywords
Cobalt treatment does not prevent glomerular morphological alterations in type 1 diabetic rats
Sign Up to like & getrecommendations! Published in 2018 at "Naunyn-Schmiedeberg's Archives of Pharmacology"
DOI: 10.1007/s00210-018-1511-7
Abstract: Early renal morphological alterations including glomerular hypertrophy and mesangial expansion occur in diabetic kidney disease and correlate with various clinical manifestations of diabetes. The present study was designed to investigate the influence of pharmacological modulation… read more here.
Keywords: glomerular morphological; mesangial expansion; morphological alterations; protein levels ... See more keywords
Specificity proteins 1 and 4 in peripheral blood mononuclear cells in postmenopausal women with schizophrenia: a 24-week double-blind, randomized, parallel, placebo-controlled trial
Sign Up to like & getrecommendations! Published in 2018 at "European Archives of Psychiatry and Clinical Neuroscience"
DOI: 10.1007/s00406-018-0938-7
Abstract: Accumulating evidence suggests that Specificity Protein 1 (SP1) and 4 (SP4) transcription factors are involved in the pathophysiology of schizophrenia. The therapeutic use of selective oestrogen modulators such as raloxifene added to antipsychotic drugs in… read more here.
Keywords: week; women schizophrenia; blood; protein levels ... See more keywords
Acetaminophen reduces the protein levels of high affinity amino acid permeases and causes tryptophan depletion
Sign Up to like & getrecommendations! Published in 2018 at "Amino Acids"
DOI: 10.1007/s00726-018-2613-8
Abstract: In yeast, toxicity of acetaminophen (APAP), a frequently used analgesic and antipyretic drug, depends on ubiquitin-controlled processes. Previously, we showed a remarkable overlap in toxicity profiles between APAP and tyrosine, and a similarity with drugs… read more here.
Keywords: amino; amino acid; acid permeases; apap ... See more keywords
The effect of dietary energy and protein levels on body weight, size, and microflora of ostrich chicks
Sign Up to like & getrecommendations! Published in 2017 at "Tropical Animal Health and Production"
DOI: 10.1007/s11250-017-1480-8
Abstract: The aim of this study was to evaluate the effect of different dietary energy and protein supplements on performance, weekly body sizes or body frame size, and microbiota of ostrich chicks during 2–9 weeks of age.… read more here.
Keywords: dietary energy; energy protein; energy; protein levels ... See more keywords
Interactive effect of exogenous protease enzyme and dietary crude protein levels on growth and digestibility indices in broiler chickens during the starter phase.
Sign Up to like & getrecommendations! Published in 2020 at "Tropical animal health and production"
DOI: 10.1007/s11250-020-02466-5
Abstract: This study was conducted to study the effect of protease as well as three dietary crude protein levels on growth and nutrient digestibility in broilers. The broiler chickens (n = 540) were assigned to six dietary treatments… read more here.
Keywords: protease enzyme; crude protein; protein levels; dietary crude ... See more keywords