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   Articles with "protein ligase" as a keyword



Ubiquitin-protein ligase E3C maintains non-small-cell lung cancer stemness by targeting AHNAK-p53 complex.

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recommendations! Published in 2019 at "Cancer letters"

DOI: 10.1016/j.canlet.2018.11.029

Abstract: Cancer stem-like cells (CSCs) are regarded as sources of tumorigenesis, metastasis, and drug resistance, which limits current cancer therapies. Elucidating the molecular modes governing CSC properties is necessary to optimize therapeutic approaches. In this study,… read more here.

Keywords: stemness; ligase e3c; cancer; p53 ... See more keywords
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Identification of Serine 119 as an Effective Inhibitor Binding Site of M. tuberculosis Ubiquitin-like Protein Ligase PafA Using Purified Proteins and M. smegmatis

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recommendations! Published in 2018 at "EBioMedicine"

DOI: 10.1016/j.ebiom.2018.03.025

Abstract: Owing to the spread of multidrug resistance (MDR) and extensive drug resistance (XDR), there is a pressing need to identify potential targets for the development of more-effective anti-M. tuberculosis (Mtb) drugs. PafA, as the sole… read more here.

Keywords: ubiquitin like; serine 119; like protein; tuberculosis ... See more keywords
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Structural Study of Potent Triazole-Based Inhibitors of Staphylococcus aureus Biotin Protein Ligase.

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recommendations! Published in 2023 at "ACS medicinal chemistry letters"

DOI: 10.1021/acsmedchemlett.2c00505

Abstract: The rise of multidrug-resistant bacteria, such as Staphylococcus aureus, has highlighted global urgency for new classes of antibiotics. Biotin protein ligase (BPL), a critical metabolic regulatory enzyme, is an important target that shows significant promise… read more here.

Keywords: staphylococcus aureus; protein ligase; triazole based; structural study ... See more keywords

Role of ubiquitin-protein ligase UBR5 in the disassembly of mitotic checkpoint complexes

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recommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"

DOI: 10.1073/pnas.2121478119

Abstract: Significance The mitotic checkpoint system is essential for the prevention of mistakes in the segregation of chromosomes in mitosis. As long as chromosomes are not attached correctly to the mitotic spindle, a mitotic checkpoint complex… read more here.

Keywords: ligase ubr5; mitotic checkpoint; ligase; checkpoint ... See more keywords
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Endosomal-associated RFFL facilitates mitochondrial clearance by enhancing PRKN/parkin recruitment to mitochondria.

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recommendations! Published in 2022 at "Autophagy"

DOI: 10.1080/15548627.2022.2052460

Abstract: Mutations in the ubiquitin ligase PRKN (parkin RBR E3 ubiquitin protein ligase) are associated with Parkinson disease and defective mitophagy. Conceptually, PRKN-dependent mitophagy is classified into two phases: 1. PRKN recruits to and ubiquitinates mitochondrial… read more here.

Keywords: ubiquitin protein; prkn parkin; protein ligase; rffl ... See more keywords
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Targeting ubiquitin protein ligase E3 component N-recognin 5 in cancer cells induces a CD8+ T cell mediated immune response

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recommendations! Published in 2020 at "Oncoimmunology"

DOI: 10.1080/2162402x.2020.1746148

Abstract: ABSTRACT UBR5 is a nuclear phosphoprotein of obscure functions. Clinical analyses reveal that UBR5 amplifications and overexpression occur in over 20% cases of human breast cancers. Breast cancer patients carrying UBR5 genetic lesions with overexpression… read more here.

Keywords: ubiquitin protein; response; protein ligase; cancer ... See more keywords
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Advanced Resistance Studies Identify Two Discrete Mechanisms in Staphylococcus aureus to Overcome Antibacterial Compounds that Target Biotin Protein Ligase

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recommendations! Published in 2020 at "Antibiotics"

DOI: 10.3390/antibiotics9040165

Abstract: Biotin protein ligase (BPL) inhibitors are a novel class of antibacterial that target clinically important methicillin-resistant Staphylococcus aureus (S. aureus). In S. aureus, BPL is a bifunctional protein responsible for enzymatic biotinylation of two biotin-dependent… read more here.

Keywords: staphylococcus aureus; biotin; bpl; resistance ... See more keywords