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Published in 2019 at "Cancer letters"
DOI: 10.1016/j.canlet.2018.11.029
Abstract: Cancer stem-like cells (CSCs) are regarded as sources of tumorigenesis, metastasis, and drug resistance, which limits current cancer therapies. Elucidating the molecular modes governing CSC properties is necessary to optimize therapeutic approaches. In this study,…
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Keywords:
stemness;
ligase e3c;
cancer;
p53 ... See more keywords
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Published in 2018 at "EBioMedicine"
DOI: 10.1016/j.ebiom.2018.03.025
Abstract: Owing to the spread of multidrug resistance (MDR) and extensive drug resistance (XDR), there is a pressing need to identify potential targets for the development of more-effective anti-M. tuberculosis (Mtb) drugs. PafA, as the sole…
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Keywords:
ubiquitin like;
serine 119;
like protein;
tuberculosis ... See more keywords
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Published in 2023 at "ACS medicinal chemistry letters"
DOI: 10.1021/acsmedchemlett.2c00505
Abstract: The rise of multidrug-resistant bacteria, such as Staphylococcus aureus, has highlighted global urgency for new classes of antibiotics. Biotin protein ligase (BPL), a critical metabolic regulatory enzyme, is an important target that shows significant promise…
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Keywords:
staphylococcus aureus;
protein ligase;
triazole based;
structural study ... See more keywords
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Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2121478119
Abstract: Significance The mitotic checkpoint system is essential for the prevention of mistakes in the segregation of chromosomes in mitosis. As long as chromosomes are not attached correctly to the mitotic spindle, a mitotic checkpoint complex…
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Keywords:
ligase ubr5;
mitotic checkpoint;
ligase;
checkpoint ... See more keywords
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Published in 2022 at "Autophagy"
DOI: 10.1080/15548627.2022.2052460
Abstract: Mutations in the ubiquitin ligase PRKN (parkin RBR E3 ubiquitin protein ligase) are associated with Parkinson disease and defective mitophagy. Conceptually, PRKN-dependent mitophagy is classified into two phases: 1. PRKN recruits to and ubiquitinates mitochondrial…
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Keywords:
ubiquitin protein;
prkn parkin;
protein ligase;
rffl ... See more keywords
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Published in 2020 at "Oncoimmunology"
DOI: 10.1080/2162402x.2020.1746148
Abstract: ABSTRACT UBR5 is a nuclear phosphoprotein of obscure functions. Clinical analyses reveal that UBR5 amplifications and overexpression occur in over 20% cases of human breast cancers. Breast cancer patients carrying UBR5 genetic lesions with overexpression…
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Keywords:
ubiquitin protein;
response;
protein ligase;
cancer ... See more keywords
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Published in 2020 at "Antibiotics"
DOI: 10.3390/antibiotics9040165
Abstract: Biotin protein ligase (BPL) inhibitors are a novel class of antibacterial that target clinically important methicillin-resistant Staphylococcus aureus (S. aureus). In S. aureus, BPL is a bifunctional protein responsible for enzymatic biotinylation of two biotin-dependent…
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Keywords:
staphylococcus aureus;
biotin;
bpl;
resistance ... See more keywords