cAMP guided his way: a life for G protein-mediated signal transduction and molecular pharmacology—tribute to Karl H. Jakobs
Sign Up to like & getrecommendations! Published in 2019 at "Naunyn-Schmiedeberg's Archives of Pharmacology"
DOI: 10.1007/s00210-019-01650-1
Abstract: Karl H. Jakobs, former editor-in-chief of Naunyn-Schmiedeberg’s Archives of Pharmacology and renowned molecular pharmacologist, passed away in April 2018. In this article, his scientific achievements regarding G protein-mediated signal transduction and regulation of canonical pathways… read more here.
Keywords: protein; protein mediated; mediated signal; karl jakobs ... See more keywords
Protein mediated regulation of the NHE1 isoform of the Na+/H+ exchanger in renal cells. A regulatory role of Hsp90 and AKT kinase.
Sign Up to like & getrecommendations! Published in 2017 at "Cellular signalling"
DOI: 10.1016/j.cellsig.2017.05.003
Abstract: Na+/H+ exchanger isoform one (NHE1) is a pH regulatory protein that is present in renal tissues and serves to remove protons from within cells and protect against intracellular acidification. NHE1 has a large 315 amino… read more here.
Keywords: protein; protein mediated; hsp90; mediated regulation ... See more keywords
Simulating Protein Mediated Hydrolysis of ATP and Other Nucleoside Triphosphates by Combining QM/MM Molecular Dynamics with Advances in Metadynamics
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Chemical Theory and Computation"
DOI: 10.1021/acs.jctc.7b00077
Abstract: The protein mediated hydrolysis of nucleoside triphosphates such as ATP or GTP is one of the most important and challenging biochemical reactions in nature. The chemical environment (water structure, catalytic metal, and amino acid residues)… read more here.
Keywords: protein mediated; methodology; molecular dynamics; hydrolysis ... See more keywords
Carrier protein mediated cargo sensing in quorum signal synthases.
Sign Up to like & getrecommendations! Published in 2023 at "Chemical communications"
DOI: 10.1039/d2cc03551k
Abstract: Acyl-homoserine lactone synthases make specific AHL quorum sensing signals to aid virulence in Gram-negative bacteria. Here, we use solution NMR spectroscopy to demonstrate that the carrier protein-enzyme interface accurately reveals substrate recognition mechanisms in two… read more here.
Keywords: quorum signal; mediated cargo; carrier protein; protein mediated ... See more keywords
Plasma Protein-Mediated Uptake and Contradictions to the Free Drug Hypothesis: A Critical Review.
Sign Up to like & getrecommendations! Published in 2023 at "Drug metabolism reviews"
DOI: 10.1080/03602532.2023.2195133
Abstract: According to the free drug hypothesis (FDH), only free, unbound drug is available to interact with biological targets. This hypothesis is the fundamental principle that continues to explain the vast majority of all pharmacokinetic and… read more here.
Keywords: plasma protein; protein mediated; drug hypothesis; mediated uptake ... See more keywords
Negative DNA supercoiling makes protein-mediated looping deterministic and ergodic within the bacterial doubling time
Sign Up to like & getrecommendations! Published in 2021 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkab946
Abstract: Abstract Protein-mediated DNA looping is fundamental to gene regulation and such loops occur stochastically in purified systems. Additional proteins increase the probability of looping, but these probabilities maintain a broad distribution. For example, the probability… read more here.
Keywords: protein; protein mediated; mediated looping; dna ... See more keywords
ChromLoops: a comprehensive database for specific protein-mediated chromatin loops in diverse organisms
Sign Up to like & getrecommendations! Published in 2022 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkac893
Abstract: Abstract Chromatin loops (or chromatin interactions) are important elements of chromatin structures. Disruption of chromatin loops is associated with many diseases, such as cancer and polydactyly. A few methods, including ChIA-PET, HiChIP and PLAC-Seq, have… read more here.
Keywords: specific protein; protein mediated; mediated chromatin; chromatin loops ... See more keywords
Protein-Mediated Carotenoid Delivery Suppresses the Photoinducible Oxidation of Lipofuscin in Retinal Pigment Epithelial Cells
Sign Up to like & getrecommendations! Published in 2023 at "Antioxidants"
DOI: 10.3390/antiox12020413
Abstract: Lipofuscin of retinal pigment epithelium (RPE) cells is a complex heterogeneous system of chromophores which accumulates as granules during the cell’s lifespan. Lipofuscin serves as a source of various cytotoxic effects linked with oxidative stress.… read more here.
Keywords: lipofuscin retinal; retinal pigment; suppresses photoinducible; protein mediated ... See more keywords