Flow Linear Dichroism of Protein-Membrane Systems.
Sign Up to like & getrecommendations! Published in 2021 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-1197-5_21
Abstract: Linear dichroism (LD) is the differential absorbance of light polarized parallel and perpendicular to an orientation direction. Any oriented sample will show a signal in its electronic as well as vibrational transitions. Model membrane small… read more here.
Keywords: flow linear; linear dichroism; dichroism protein; protein membrane ... See more keywords
Estimating the Accuracy of the Martini Model Towards the Investigation of Peripheral Protein - Membrane Interactions
Sign Up to like & getrecommendations! Published in 2021 at "Biophysical Journal"
DOI: 10.1016/j.bpj.2020.11.1540
Abstract: Peripheral membrane proteins play a major role in numerous biological processes by transiently associating with cellular membranes, often with extreme membrane specificity. Because of the short-lived nature of these interactions, molecular dynamics (MD) simulations have… read more here.
Keywords: peripheral proteins; protein membrane; estimating accuracy; membrane ... See more keywords
Predicting protein–membrane interfaces of peripheral membrane proteins using ensemble machine learning
Sign Up to like & getrecommendations! Published in 2022 at "Briefings in Bioinformatics"
DOI: 10.1093/bib/bbab518
Abstract: Abstract Abnormal protein–membrane attachment is involved in deregulated cellular pathways and in disease. Therefore, the possibility to modulate protein–membrane interactions represents a new promising therapeutic strategy for peripheral membrane proteins that have been considered so… read more here.
Keywords: peripheral membrane; predicting protein; membrane proteins; machine learning ... See more keywords
DREAMM: a web-based server for drugging protein-membrane interfaces as a novel workflow for targeted drug design
Sign Up to like & getrecommendations! Published in 2022 at "Bioinformatics"
DOI: 10.1093/bioinformatics/btac680
Abstract: Abstract Summary The allosteric modulation of peripheral membrane proteins (PMPs) by targeting protein-membrane interactions with drug-like molecules represents a new promising therapeutic strategy for proteins currently considered undruggable. However, the accessibility of protein-membrane interfaces by… read more here.
Keywords: membrane interfaces; dreamm; membrane; drugging protein ... See more keywords
Dissecting peripheral protein-membrane interfaces
Sign Up to like & getrecommendations! Published in 2022 at "PLOS Computational Biology"
DOI: 10.1371/journal.pcbi.1010346
Abstract: Peripheral membrane proteins (PMPs) include a wide variety of proteins that have in common to bind transiently to the chemically complex interfacial region of membranes through their interfacial binding site (IBS). In contrast to protein-protein… read more here.
Keywords: membrane interfaces; peripheral protein; membrane; dissecting peripheral ... See more keywords
Single-molecule force spectroscopy of protein-membrane interactions
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DOI: 10.7554/elife.30493
Abstract: Many biological processes rely on protein–membrane interactions in the presence of mechanical forces, yet high resolution methods to quantify such interactions are lacking. Here, we describe a single-molecule force spectroscopy approach to quantify membrane binding… read more here.
Keywords: single molecule; protein membrane; spectroscopy; membrane interactions ... See more keywords