Proteins and Metabolites fingerprints of Gestational Diabetes Mellitus forming Protein-Metabolite Interactomes are its potential biomarkers.
Sign Up to like & getrecommendations! Published in 2023 at "Proteomics"
DOI: 10.1002/pmic.202200257
Abstract: Gestational diabetes mellitus (GDM) is a consequence of glucose intolerance with an inadequate production of insulin that happens during pregnancy and leads to adverse health consequences for both mother and fetus. GDM patients are at… read more here.
Keywords: gdm; metabolites fingerprints; protein metabolite; proteins metabolites ... See more keywords
Towards detecting regulatory protein-metabolite interactions.
Sign Up to like & getrecommendations! Published in 2017 at "Current opinion in microbiology"
DOI: 10.1016/j.mib.2017.07.006
Abstract: New mapping approaches have greatly expanded our view on the cellular landscape of protein-metabolite interactions. These methods either identify proteins interacting with a selected metabolite or vice versa. By reviewing recent developments, we found that… read more here.
Keywords: protein; detecting regulatory; regulatory protein; metabolite interactions ... See more keywords
Global mapping of protein–metabolite interactions in Saccharomyces cerevisiae reveals that Ser-Leu dipeptide regulates phosphoglycerate kinase activity
Sign Up to like & getrecommendations! Published in 2021 at "Communications Biology"
DOI: 10.1038/s42003-021-01684-3
Abstract: Protein–metabolite interactions are of crucial importance for all cellular processes but remain understudied. Here, we applied a biochemical approach named PROMIS, to address the complexity of the protein–small molecule interactome in the model yeast Saccharomyces… read more here.
Keywords: protein; dipeptide; saccharomyces cerevisiae; metabolite interactions ... See more keywords
Robust Huber-LASSO for improved prediction of protein, metabolite and gene expression levels relying on individual genotype data
Sign Up to like & getrecommendations! Published in 2021 at "Briefings in Bioinformatics"
DOI: 10.1093/bib/bbaa230
Abstract: Abstract Least absolute shrinkage and selection operator (LASSO) regression is often applied to select the most promising set of single nucleotide polymorphisms (SNPs) associated with a molecular phenotype of interest. While the penalization parameter λ… read more here.
Keywords: protein metabolite; lasso; robust huber; expression ... See more keywords
Heritability of Protein and Metabolite Biomarkers Associated with COVID-19 Severity: A Metabolomics and Proteomics Analysis
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DOI: 10.3390/biom13010046
Abstract: Objectives: Prior studies have characterized protein and metabolite changes associated with SARS-CoV-2 infection; we hypothesized that these biomarkers may be part of heritable metabolic pathways in erythrocytes. Methods: Using a twin study of erythrocyte protein… read more here.
Keywords: metabolism; heritability; protein metabolite; covid severity ... See more keywords
Identifying Protein–metabolite Networks Associated with COPD Phenotypes
Sign Up to like & getrecommendations! Published in 2020 at "Metabolites"
DOI: 10.3390/metabo10040124
Abstract: Chronic obstructive pulmonary disease (COPD) is a disease in which airflow obstruction in the lung makes it difficult for patients to breathe. Although COPD occurs predominantly in smokers, there are still deficits in our understanding… read more here.
Keywords: protein metabolite; networks associated; copd; identifying protein ... See more keywords