Controlling Amphiphilic Polymer Folding beyond the Primary Structure with Protein-Mimetic Di(Phenylalanine).
Sign Up to like & getrecommendations! Published in 2021 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.1c05659
Abstract: While methods for polymer synthesis have proliferated, their functionality pales in comparison to natural biopolymers-strategies are limited for building the intricate network of noncovalent interactions necessary to elicit complex, protein-like functions. Using a bioinspired di(phenylalanine)… read more here.
Keywords: protein mimetic; polymer; phenylalanine; sheet like ... See more keywords
Rational Construction of Protein-Mimetic Nano-Switch Systems Based on Secondary Structure Transitions of Synthetic Polypeptides.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.3c01156
Abstract: The manipulation of the flexibility/rigidity of polymeric chains to control their function is commonly observed in natural macromolecules but largely unexplored in synthetic systems. Herein, we construct a series of protein-mimetic nano-switches consisting of a… read more here.
Keywords: polypeptide; nano; structure; protein mimetic ... See more keywords
Construction of a Sequenceable Protein Mimetic Peptide Library with a True 3D Diversifiable Chemical Space.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.8b08338
Abstract: We present here a library of protein mimetic bicyclic peptides. These nanosized structures exhibit rigid backbones and spatially diversifiable side chains. They present modular amino acids on all three linkages, providing access to a true… read more here.
Keywords: protein mimetic; chemical space; true diversifiable; diversifiable chemical ... See more keywords
Protein-mimetic peptoid nanoarchitectures for pathogen recognition and neutralization.
Sign Up to like & getrecommendations! Published in 2022 at "Nanoscale"
DOI: 10.1039/d2nr05326h
Abstract: Recent outbreaks of both new and existing infectious pathogens have threatened healthcare systems around the world. Therefore, it is vital to detect and neutralize pathogens to prevent their spread and treat infected patients. This consideration… read more here.
Keywords: mimetic peptoid; nanoarchitectures pathogen; protein mimetic; neutralization ... See more keywords
Bacterial Protein Mimetic of Peptide Hormone as a New Class of Protein- based Drugs.
Sign Up to like & getrecommendations! Published in 2019 at "Current medicinal chemistry"
DOI: 10.2174/0929867324666171005110620
Abstract: Specific peptide molecules classified as hormones, neuropeptides and cytokines are involved in intercellular signaling regulating various physiological processes in all organs and tissues. This justifies the peptidergic signaling as an attractive pharmacological target. Recently, a… read more here.
Keywords: protein; protein mimetic; peptide; protein based ... See more keywords