Nanoscale Discrimination between Toxic and Nontoxic Protein Misfolded Oligomers with Tip-Enhanced Raman Spectroscopy.
Sign Up to like & getrecommendations! Published in 2018 at "Small"
DOI: 10.1002/smll.201800890
Abstract: Highly toxic protein misfolded oligomers associated with neurological disorders such as Alzheimer's and Parkinson's diseases are nowadays considered primarily responsible for promoting synaptic failure and neuronal death. Unraveling the relationship between structure and neurotoxicity of… read more here.
Keywords: protein; enhanced raman; tip enhanced; misfolded oligomers ... See more keywords
Frequent contiguous pattern mining over biological sequences of protein misfolded diseases
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DOI: 10.1186/s12859-021-04341-y
Abstract: Background Proteins are integral part of all living beings, which are building blocks of many amino acids. To be functionally active, amino acids chain folds up in a complex way to give each protein a… read more here.
Keywords: frequent contiguous; amino acids; misfolded diseases; association ... See more keywords
Chaperones as Suppressors of Protein Misfolded Oligomer Toxicity
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DOI: 10.3389/fnmol.2017.00098
Abstract: Chaperones have long been recognized to play well defined functions such as to: (i) assist protein folding and promote formation and maintenance of multisubunit complexes; (ii) mediate protein degradation; (iii) inhibit protein aggregation; and (iv)… read more here.
Keywords: aberrant protein; protein aggregates; toxicity; chaperones suppressors ... See more keywords