Biophysical and Spectroscopic Methods for Monitoring Protein Misfolding and Amyloid Aggregation.
Sign Up to like & getrecommendations! Published in 2019 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-8820-4_1
Abstract: Proteins exhibit a remarkable structural plasticity and may undergo conformational changes resulting in protein misfolding both in a biological context and upon perturbing physiopathological conditions. Such nonfunctional protein conformers, including misfolded states and aggregates, are… read more here.
Keywords: protein; protein misfolding; aggregation; biophysical spectroscopic ... See more keywords
Protein misfolding in endoplasmic reticulum stress with applications to renal diseases.
Sign Up to like & getrecommendations! Published in 2019 at "Advances in protein chemistry and structural biology"
DOI: 10.1016/bs.apcsb.2019.08.001
Abstract: Protein misfolding may be the result of a variety of different processes that disrupt the ability of a protein to form a thermodynamically stable tertiary structure that allows it to perform its proper function. In… read more here.
Keywords: endoplasmic reticulum; reticulum stress; protein misfolding; renal diseases ... See more keywords
Combining molecular dynamics simulations and experimental analyses in protein misfolding.
Sign Up to like & getrecommendations! Published in 2019 at "Advances in protein chemistry and structural biology"
DOI: 10.1016/bs.apcsb.2019.10.001
Abstract: The fold of a protein determines its function and its misfolding can result in loss-of-function defects. In addition, for certain proteins their misfolding can lead to gain-of-function toxicities resulting in protein misfolding diseases such as… read more here.
Keywords: protein misfolding; molecular dynamics; experimental analyses; combining molecular ... See more keywords
Living with the enemy: from protein-misfolding pathologies we know, to those we want to know
Sign Up to like & getrecommendations! Published in 2021 at "Ageing Research Reviews"
DOI: 10.1016/j.arr.2021.101391
Abstract: Conformational diseases are caused by the aggregation of misfolded proteins. The risk for such pathologies develops years before clinical symptoms appear, and is higher in people with alpha-1 antitrypsin (AAT) polymorphisms. Thousands of people with… read more here.
Keywords: protein misfolding; misfolding pathologies; enemy protein; know want ... See more keywords
AAA+ Protein-Based Technologies to Counter Neurodegenerative Disease.
Sign Up to like & getrecommendations! Published in 2019 at "Biophysical journal"
DOI: 10.1016/j.bpj.2019.03.007
Abstract: Protein misfolding and overloaded proteostasis networks underlie a range of neurodegenerative diseases. No cures exist for these diseases, but developing effective therapeutic agents targeting the toxic, misfolded protein species in disease is one promising strategy. AAA+… read more here.
Keywords: protein; protein misfolding; neurodegenerative disease; aaa protein ... See more keywords
Protein misfolding, aggregation and mechanism of amyloid cytotoxicity: An overview and therapeutic strategies to inhibit aggregation.
Sign Up to like & getrecommendations! Published in 2019 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2019.05.109
Abstract: Protein and peptides are converted from their soluble forms into highly ordered fibrillar aggregates under various conditions inside the cell. Such transitions confer diverse neurodegenerative diseases including Alzheimer's disease, Huntington's disease Prion's disease, Parkinson's disease,… read more here.
Keywords: protein; protein misfolding; aggregation; mechanism amyloid ... See more keywords
Consequences of inner mitochondrial membrane protein misfolding.
Sign Up to like & getrecommendations! Published in 2019 at "Mitochondrion"
DOI: 10.1016/j.mito.2019.06.001
Abstract: Proteins embedded in the inner mitochondrial membrane (IMM) perform essential cellular functions. Maintaining the folding state of these proteins is therefore of the utmost importance, and this is ensured by IMM chaperones and proteases that… read more here.
Keywords: protein; protein misfolding; imm; inner mitochondrial ... See more keywords
Characterization of Pairs of Toxic and Nontoxic Misfolded Protein Oligomers Elucidates the Structural Determinants of Oligomer Toxicity in Protein Misfolding Diseases.
Sign Up to like & getrecommendations! Published in 2023 at "Accounts of chemical research"
DOI: 10.1021/acs.accounts.3c00045
Abstract: ConspectusThe aberrant misfolding and aggregation of peptides and proteins into amyloid aggregates occurs in over 50 largely incurable protein misfolding diseases. These pathologies include Alzheimer's and Parkinson's diseases, which are global medical emergencies owing to… read more here.
Keywords: misfolding diseases; misfolded protein; protein misfolding; toxic nontoxic ... See more keywords
Modulating Conformation of Aβ-Peptide: An Effective Way to Prevent Protein-Misfolding Disease.
Sign Up to like & getrecommendations! Published in 2018 at "Inorganic chemistry"
DOI: 10.1021/acs.inorgchem.8b02115
Abstract: Alzheimer's disease (AD) is a typical protein-misfolding disease. Aggregation of amyloid β-peptide (Aβ) plays a key role in the etiology of AD. The misfolding of Aβ results in the formation of β-sheet-rich aggregates and damages… read more here.
Keywords: protein misfolding; misfolding disease; cam; disease ... See more keywords
An integrated bacterial system for the discovery of chemical rescuers of disease-associated protein misfolding
Sign Up to like & getrecommendations! Published in 2017 at "Nature Biomedical Engineering"
DOI: 10.1038/s41551-017-0144-3
Abstract: Protein misfolding and aggregation are common pathological features of several human diseases, including Alzheimer’s disease and type 2 diabetes. Here, we report an integrated and generalizable bacterial system for the facile discovery of chemical rescuers… read more here.
Keywords: protein misfolding; protein; system; alzheimer disease ... See more keywords
Screening methods for identifying pharmacological chaperones.
Sign Up to like & getrecommendations! Published in 2017 at "Molecular bioSystems"
DOI: 10.1039/c6mb00866f
Abstract: Protein folding is crucial for most proteins to achieve their correct three-dimensional conformations and function properly. Defects in protein folding frequently caused by mutations lead to a range of protein misfolding diseases, including Alzheimer's disease,… read more here.
Keywords: protein misfolding; screening methods; methods identifying; misfolding diseases ... See more keywords