YAP nuclear‐cytoplasmic translocation is regulated by mechanical signaling, protein modification, and metabolism
Sign Up to like & getrecommendations! Published in 2020 at "Cell Biology International"
DOI: 10.1002/cbin.11345
Abstract: Nuclear‐cytoplasmic transport is necessary for the biological function of nuclear proteins. The mechanism underlying this process is very complex and has been a subject of intense research. Yes‐associated protein (YAP), a Hippo signaling pathway effector,… read more here.
Keywords: protein; signaling protein; nuclear cytoplasmic; protein modification ... See more keywords
Designing Selectivity in Dirhodium Metallopeptide Catalysts for Protein Modification.
Sign Up to like & getrecommendations! Published in 2017 at "Bioconjugate chemistry"
DOI: 10.1021/acs.bioconjchem.6b00716
Abstract: The ability to chemically alter proteins is important for broad areas of chemical biology, biophysics, and medicine. Chemical catalysts for protein modification, and particularly rhodium(II) conjugates, represent an important new approach to protein modification that… read more here.
Keywords: selectivity dirhodium; catalysts protein; protein modification; dirhodium metallopeptide ... See more keywords
Challenges in the use of sortase and other peptide ligases for site-specific protein modification
Sign Up to like & getrecommendations! Published in 2022 at "Chemical Society Reviews"
DOI: 10.1039/d0cs01148g
Abstract: Site-specific protein modification is a widely-used biochemical tool. However, there are many challenges associated with the development of protein modification techniques, in particular, achieving site-specificity, reaction efficiency and versatility. The engineering of peptide ligases and… read more here.
Keywords: site specific; site; protein modification; peptide ligases ... See more keywords
Protein modification with ISG15 blocks coxsackievirus pathology by antiviral and metabolic reprogramming
Sign Up to like & getrecommendations! Published in 2020 at "Science Advances"
DOI: 10.1126/sciadv.aay1109
Abstract: Protein modification with ISG15 acts cooperatively with IFIT proteins and preserves glucose homeostasis. Protein modification with ISG15 (ISGylation) represents a major type I IFN–induced antimicrobial system. Common mechanisms of action and species-specific aspects of ISGylation,… read more here.
Keywords: modification isg15; protein modification; isgylation; pathology ... See more keywords
Effects of the Acetyltransferase p300 on Tumour Regulation from the Novel Perspective of Posttranslational Protein Modification
Sign Up to like & getrecommendations! Published in 2023 at "Biomolecules"
DOI: 10.3390/biom13030417
Abstract: p300 acts as a transcription coactivator and an acetyltransferase that plays an important role in tumourigenesis and progression. In previous studies, it has been confirmed that p300 is an important regulator in regulating the evolution… read more here.
Keywords: acetyltransferase; protein modification; modification; tumour cell ... See more keywords
O-GlcNAcylation: An Emerging Protein Modification Regulating the Hippo Pathway
Sign Up to like & getrecommendations! Published in 2022 at "Cancers"
DOI: 10.3390/cancers14123013
Abstract: Simple Summary The contact point between the Hippo pathway, which serves as a central hub for various external environments, and O-GlcNAcylation, which is a non-canonical glycosylation process acting as a dynamic regulator in various signal… read more here.
Keywords: protein modification; hippo pathway; pathway dysregulation; glcnacylation ... See more keywords
Protein Modification Employing Non-Canonical Amino Acids to Prepare SUMOylation Detecting Bioconjugates
Sign Up to like & getrecommendations! Published in 2022 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics14122826
Abstract: Protein modification with non-canonical amino acids (ncAAs) represents a useful technology to afford homogenous samples of bioconjugates with site-specific modification. This technique can be directly applied to the detection of aberrant SUMOylation patterns, which are… read more here.
Keywords: amino acids; protein modification; modification; non canonical ... See more keywords