Protein Modifications with Ubiquitin as Response to Cerebral Ischemia-Reperfusion Injury
Sign Up to like & getrecommendations! Published in 2017 at "Translational Stroke Research"
DOI: 10.1007/s12975-017-0567-x
Abstract: Post-translational protein modifications present an elegant and energy efficient way to dynamically reprogram cellular protein properties and functions in response to homeostatic imbalance. One such protein modification is the tagging of proteins with the small… read more here.
Keywords: protein; response; cerebral ischemia; protein modifications ... See more keywords
Degenerative protein modifications in the aging vasculature and central nervous system: A problem shared is not always halved
Sign Up to like & getrecommendations! Published in 2019 at "Ageing Research Reviews"
DOI: 10.1016/j.arr.2019.100909
Abstract: Aging influences the pathogenesis and progression of several major diseases affecting both the cardiovascular system (CVS) and central nervous system (CNS). Defining the common molecular features that underpin these disorders in these crucial body systems… read more here.
Keywords: system; nervous system; central nervous; protein modifications ... See more keywords
Stable isotope labeling by fatty acids in cell culture (SILFAC) coupled with isotope pattern dependent mass spectrometry for global screening of lipid hydroperoxide-mediated protein modifications.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of proteomics"
DOI: 10.1016/j.jprot.2017.07.006
Abstract: Lipid hydroperoxide-mediated modifications of proteins are receiving increasing attention because of their possible involvement in various degenerative diseases. These biological effects are attributed to the ability of lipid peroxidation-derived aldehydes to react with the nucleophilic… read more here.
Keywords: methodology; isotope; hydroperoxide mediated; lipid hydroperoxide ... See more keywords
Intrinsic protein disorder and protein modifications in the processing of biological signals.
Sign Up to like & getrecommendations! Published in 2019 at "Current opinion in structural biology"
DOI: 10.1016/j.sbi.2019.09.003
Abstract: Eukaryotic cells are highly complex systems; however, they manage to attain this complexity with a surprisingly small number of protein products. This is due, in part, to the fact that the functions of the eukaryotic… read more here.
Keywords: protein; intrinsic protein; protein disorder; biological signals ... See more keywords
A Novel Strategy Based on Permanent Protein Modifications Induced by Formaldehyde for Food Safety Analysis.
Sign Up to like & getrecommendations! Published in 2022 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.2c04069
Abstract: The illegal additions of chemicals in food products are serious incidents threatening current public safety. To date, ideal methods to determine permanent traces of prohibited chemicals in foods are still lacking. For example, formaldehyde (FA)… read more here.
Keywords: safety; modifications induced; food; protein modifications ... See more keywords
PTMselect: optimization of protein modifications discovery by mass spectrometry
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-40873-3
Abstract: Discovery of protein modification sites relies on protein digestion by proteases and mass spectrometry (MS) identification of the modified peptides. Depending on proteases used and target protein sequence, this method yields highly variable coverage of… read more here.
Keywords: protein; mass spectrometry; ptmselect optimization; optimization protein ... See more keywords
Non-specific protein modifications may be novel mechanism underlying bioactive phytochemicals
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Clinical Biochemistry and Nutrition"
DOI: 10.3164/jcbn.17-113
Abstract: In a variety of experimental models, dietary phytochemicals have been demonstrated to exhibit pronounced and versatile bioactivities. Importantly, the possibility of such phytochemicals for human application has been supported in part by epidemiological surveys, which… read more here.
Keywords: modifications may; non specific; specific protein; may novel ... See more keywords
The Role of Histone Protein Modifications and Mutations in Histone Modifiers in Pediatric B-Cell Progenitor Acute Lymphoblastic Leukemia
Sign Up to like & getrecommendations! Published in 2017 at "Cancers"
DOI: 10.3390/cancers9010002
Abstract: While cancer has been long recognized as a disease of the genome, the importance of epigenetic mechanisms in neoplasia was acknowledged more recently. The most active epigenetic marks are DNA methylation and histone protein modifications… read more here.
Keywords: histone; role; histone protein; cell ... See more keywords