Elicitation of Potent Neutralizing Antibody Responses by Designed Protein Nanoparticle Vaccines for SARS-CoV-2
Sign Up to like & getrecommendations! Published in 2020 at "Cell"
DOI: 10.1016/j.cell.2020.10.043
Abstract: A safe, effective, and scalable vaccine is needed to halt the ongoing SARS-CoV-2 pandemic. We describe the structure-based design of self-assembling protein nanoparticle immunogens that elicit potent and protective antibody responses against SARS-CoV-2 in mice.… read more here.
Keywords: protein nanoparticle; nanoparticle; nanoparticle vaccines; sars cov ... See more keywords
Engineering Protein-Nanoparticle Hybrids as Targeted Contrast Agents.
Sign Up to like & getrecommendations! Published in 2024 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.4c12799
Abstract: Iron oxide nanoparticles (IONPs) have shown great promise in biomedical applications, particularly as MRI contrast agents due to their magnetic properties and biocompatibility. Although several IONPs have been approved by regulatory agencies as MRI contrast… read more here.
Keywords: protein nanoparticle; engineering protein; contrast agents; contrast ... See more keywords
Protein Nanoparticle-Mediated Delivery of Recombinant Influenza Hemagglutinin Enhances Immunogenicity and Breadth of the Antibody Response
Sign Up to like & getrecommendations! Published in 2023 at "ACS Infectious Diseases"
DOI: 10.1021/acsinfecdis.2c00362
Abstract: The vast majority of seasonal influenza vaccines administered each year are derived from virus propagated in eggs using technology that has changed little since the 1930s. The immunogenicity, durability, and breadth of response would likely… read more here.
Keywords: immunogenicity; influenza; protein nanoparticle; breadth ... See more keywords
Stress granules attenuate protein nanoparticle induced osmotic imbalance via membrane potential restoration
Sign Up to like & getrecommendations! Published in 2025 at "Scientific Reports"
DOI: 10.1038/s41598-025-12903-w
Abstract: Stress granules (SGs) are biomolecular condensates formed in response to stress stimuli, and they can alter intracellular protein particles. Here, SG assembly was noted to effectively stabilize intermediate filament tension, intracellular osmolarity, Ca2+ signaling, and… read more here.
Keywords: protein nanoparticle; stress granules; osmotic pressure; membrane potential ... See more keywords
Naturally-Derived PHA-L Protein Nanoparticle as a Radioprotector Through Activation of Toll-Like Receptor 5.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of biomedical nanotechnology"
DOI: 10.1166/jbn.2019.2665
Abstract: High energy ray in medical diagnosis and therapy can benefit to patients, but can also cause the significant damages to biomolecules such as DNA, as well as free radical generation, inevitably leading to numerous side… read more here.
Keywords: toll like; protein nanoparticle; nanoparticle; like receptor ... See more keywords
Protein Nanoparticle-Related Osmotic Pressure Modifies Nonselective Permeability of the Blood–Brain Barrier by Increasing Membrane Fluidity
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Nanomedicine"
DOI: 10.2147/ijn.s291286
Abstract: Background Intracellular tension plays a crucial role in the destruction of the blood–brain barrier (BBB) in response to lesion stimuli. Tight junction structure could be primarily affected by tension activity. In this study, we aimed… read more here.
Keywords: osmotic pressure; related osmotic; tension; protein nanoparticle ... See more keywords
Design and immunological evaluation of two-component protein nanoparticle vaccines for East Coast fever
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.1015840
Abstract: Nanoparticle vaccines usually prime stronger immune responses than soluble antigens. Within this class of subunit vaccines, the recent development of computationally designed self-assembling two-component protein nanoparticle scaffolds provides a powerful and versatile platform for displaying… read more here.
Keywords: nanoparticle; component protein; protein nanoparticle; two component ... See more keywords
A Review for Uncovering the “Protein-Nanoparticle Alliance”: Implications of the Protein Corona for Biomedical Applications
Sign Up to like & getrecommendations! Published in 2024 at "Nanomaterials"
DOI: 10.3390/nano14100823
Abstract: Understanding both the physicochemical and biological interactions of nanoparticles is mandatory for the biomedical application of nanomaterials. By binding proteins, nanoparticles acquire new surface identities in biological fluids, the protein corona. Various studies have revealed… read more here.
Keywords: protein nanoparticle; protein corona; protein; nanoparticle alliance ... See more keywords
A Thermal-Stable Protein Nanoparticle That Stimulates Long Lasting Humoral Immune Response
Sign Up to like & getrecommendations! Published in 2023 at "Vaccines"
DOI: 10.3390/vaccines11020426
Abstract: A thermally stable vaccine platform is considered the missing piece of vaccine technology. In this article, we reported the creation of a novel protein nanoparticle and assessed its ability to withstand extended high temperature incubation… read more here.
Keywords: nanoparticle; humoral immune; long lasting; protein nanoparticle ... See more keywords