Macromolecular Cargo Encapsulation via In Vitro Assembly of Two‐Component Protein Nanoparticles
Sign Up to like & getrecommendations! Published in 2024 at "Advanced Healthcare Materials"
DOI: 10.1002/adhm.202303910
Abstract: Self‐assembling protein nanoparticles are a promising class of materials for targeted drug delivery. Here, the use of a computationally designed, two‐component, icosahedral protein nanoparticle is reported to encapsulate multiple macromolecular cargoes via simple and controlled… read more here.
Keywords: via vitro; vitro assembly; protein; two component ... See more keywords
Protein Nanoparticles: Uniting the Power of Proteins with Engineering Design Approaches
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Science"
DOI: 10.1002/advs.202104012
Abstract: Protein nanoparticles, PNPs, have played a long‐standing role in food and industrial applications. More recently, their potential in nanomedicine has been more widely pursued. This review summarizes recent trends related to the preparation, application, and… read more here.
Keywords: uniting power; protein nanoparticles; power proteins; proteins engineering ... See more keywords
Electrohydrodynamic Jetting of Mucoadhesive Protein Nanoparticles as a Chemopreventive Strategy for Oral Squamous Cell Carcinoma
Sign Up to like & getrecommendations! Published in 2025 at "Macromolecular Bioscience"
DOI: 10.1002/mabi.202400661
Abstract: Intraepithelial delivery of cancer preventive therapies for oral squamous cell carcinoma (OSCC) has been limited by factors such as rapid mucus turnover, enzymatic degradation, and salivary clearance. These challenges, coupled with poor solubility and associated… read more here.
Keywords: oral squamous; mucoadhesive protein; squamous cell; cell carcinoma ... See more keywords
Entrapment of β-carotene and zinc in whey protein nanoparticles using the pH cycle method: Evidence of sustained release delivery in intestinal and gastric fluids
Sign Up to like & getrecommendations! Published in 2018 at "Food Bioscience"
DOI: 10.1016/j.fbio.2018.10.002
Abstract: Abstract Nanoparticles prepared from whey protein isolates were used for the entrapment and sustained delivery of β-carotene and Zn ions. The loaded whey protein nanoparticles were prepared using the pH cycle method at an aggregation… read more here.
Keywords: carotene; protein nanoparticles; using cycle; delivery ... See more keywords
Formation and characterization of soy protein nanoparticles by controlled partial enzymatic hydrolysis
Sign Up to like & getrecommendations! Published in 2020 at "Food Hydrocolloids"
DOI: 10.1016/j.foodhyd.2020.105844
Abstract: Abstract In the present study, the potential of enzymatic hydrolysis as an efficient approach for the fabrication of soy protein nanoparticles (SPNPs) was investigated. Three types of enzymes including Flavorzyme, Alcalase and Protamex were selected… read more here.
Keywords: soy protein; protein nanoparticles; enzymatic hydrolysis; formation ... See more keywords
Alginate/chitosan microparticles for gastric passage and intestinal release of therapeutic protein nanoparticles
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Controlled Release"
DOI: 10.1016/j.jconrel.2018.12.017
Abstract: Abstract Enzymes with intracellular activity have significant potential to treat diseases. Protein nanoparticles (NPs) considerably enhance intracellular delivery of enzymes. We have previously shown that a Salmonella effector enzyme, AvrA, delivered by NPs is capable… read more here.
Keywords: protein; alginate chitosan; protein nps; protein nanoparticles ... See more keywords
Characterisation of porous anodic alumina membranes for ultrafiltration of protein nanoparticles as a size mimic of virus particles
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Membrane Science"
DOI: 10.1016/j.memsci.2019.02.071
Abstract: Abstract Viral vectors used in emerging gene therapies face challenges of significant yield loss during downstream processing primarily due to their large size, fragility and mass transfer limitations of the traditional porous chromatography adsorbents. The… read more here.
Keywords: anodic alumina; porous anodic; ultrafiltration; protein nanoparticles ... See more keywords
Oral administration of protein nanoparticles: An emerging route to disease treatment.
Sign Up to like & getrecommendations! Published in 2020 at "Pharmacological research"
DOI: 10.1016/j.phrs.2020.104685
Abstract: Over the last two decades, developments in nanomedicine have resulted in technical advances with application to clinical science. Both organic and inorganic nanoparticles (NPs) have shown tolerability, pharmacologic specificity and biodegradability. A subclass of NPs,… read more here.
Keywords: protein; oral delivery; protein nps; protein nanoparticles ... See more keywords
Engineering Self-Assembling Protein Nanoparticles for Therapeutic Delivery
Sign Up to like & getrecommendations! Published in 2022 at "Bioconjugate Chemistry"
DOI: 10.1021/acs.bioconjchem.2c00030
Abstract: Despite remarkable advances over the past several decades, many therapeutic nanomaterials fail to overcome major in vivo delivery barriers. Controlling immunogenicity, optimizing biodistribution, and engineering environmental responsiveness are key outstanding delivery problems for most nanotherapeutics.… read more here.
Keywords: therapeutic delivery; assembling protein; protein nanoparticles; self assembling ... See more keywords
Multicolored Protein Nanoparticles: Synthesis, Characterization, and Cell Uptake.
Sign Up to like & getrecommendations! Published in 2018 at "Bioconjugate chemistry"
DOI: 10.1021/acs.bioconjchem.8b00282
Abstract: Synthesis, characterization, and applications of strongly fluorescent, multicolored protein nanoparticles (GlowDots) are reported here. Bovine serum albumin was cross-linked under controlled conditions to form nanoparticles, where particle size was controlled from 20 to 100 ±… read more here.
Keywords: characterization cell; multicolored protein; protein nanoparticles; nanoparticles synthesis ... See more keywords
Biomimetic SARS-CoV-2 Spike Protein Nanoparticles
Sign Up to like & getrecommendations! Published in 2023 at "Biomacromolecules"
DOI: 10.1021/acs.biomac.2c01465
Abstract: COVID-19 is an infectious respiratory disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). This virus contains a crucial coat protein that engages with target cells via a receptor binding domain (RBD) on… read more here.
Keywords: cov spike; protein nanoparticles; spike protein; biomimetic sars ... See more keywords