Hedgehog signaling negatively co-regulates BH3-only protein Noxa and TAp73 in TP53-mutated cells.
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DOI: 10.1016/j.canlet.2018.04.025
Abstract: In the present study, we show that pharmacological repression by the Hedgehog (Hh) pathway inhibitor (HPI) GANT61 induces expression of the proapoptotic protein Noxa in TP53-mutated embryonal pediatric tumor cells driven by Hh signaling (i.e.… read more here.
Keywords: protein; protein noxa; tp53 mutated; noxa tap73 ... See more keywords