MORC3 Is a Target of the Influenza A Viral Protein NS1.
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DOI: 10.1016/j.str.2019.03.015
Abstract: Microrchidia 3 (MORC3), a human ATPase linked to several autoimmune disorders, has been characterized both as a negative and positive regulator of influenza A virus. Here, we report that the CW domain of MORC3 (MORC3-CW)… read more here.
Keywords: protein; morc3 target; target influenza; protein ns1 ... See more keywords
Cross-reactive antibodies targeting surface-exposed non-structural protein 1 (NS1) of dengue virus-infected cells recognize epitopes on the spaghetti loop of the β-ladder domain
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DOI: 10.1371/journal.pone.0266136
Abstract: Non-structural protein 1 (NS1) is a glycoprotein component of dengue virus (DENV) that is essential for viral replication, infection and immune evasion. Immunization with NS1 has been shown to elicit antibody-mediated immune responses which protect… read more here.
Keywords: structural protein; protein ns1; dengue; non structural ... See more keywords
The Dual Role of the Antibody Response Against the Flavivirus Non-structural Protein 1 (NS1) in Protection and Immuno-Pathogenesis
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2019.01651
Abstract: Dengue and Zika viruses are closely related mosquito-borne flaviviruses responsible for major public health problems in tropical and sub-tropical countries. The genomes of both, dengue and zika viruses encodes 10 genes that are translated into… read more here.
Keywords: protein; structural protein; protein ns1; dengue zika ... See more keywords
The Central Role of Non-Structural Protein 1 (NS1) in Influenza Biology and Infection
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DOI: 10.3390/ijms21041511
Abstract: Influenza (flu) is a contagious viral disease, which targets the human respiratory tract and spreads throughout the world each year. Every year, influenza infects around 10% of the world population and between 290,000 and 650,000… read more here.
Keywords: structural protein; protein ns1; non structural; biology ... See more keywords
Unveiling New Druggable Pockets in Influenza Non-Structural Protein 1: NS1–Host Interactions as Antiviral Targets for Flu
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DOI: 10.3390/ijms24032977
Abstract: Influenza viruses are responsible for significant morbidity and mortality worldwide in winter seasonal outbreaks and in flu pandemics. Influenza viruses have a high rate of evolution, requiring annual vaccine updates and severely diminishing the effectiveness… read more here.
Keywords: druggable pockets; structural protein; protein ns1; non structural ... See more keywords
Design and Characterization of Mutated Variants of the Oncotoxic Parvoviral Protein NS1
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DOI: 10.3390/v15010209
Abstract: Oncotoxic proteins such as the non-structural protein 1 (NS1), a constituent of the rodent parvovirus H1 (H1-PV), offer a novel approach for treatment of tumors that are refractory to other treatments. In the present study,… read more here.
Keywords: ns1 variants; protein ns1; ns1; protein ... See more keywords