Modeling protein-nucleic acid complexes with extremely large conformational changes using Flex-LZerD.
Sign Up to like & getrecommendations! Published in 2022 at "Proteomics"
DOI: 10.1002/pmic.202200322
Abstract: Proteins and nucleic acids are key components in many processes in living cells, and interactions between proteins and nucleic acids are often crucial pathway components. In many cases, large flexibility of proteins as they interact… read more here.
Keywords: flex lzerd; acid complexes; protein nucleic; nucleic acid ... See more keywords
High-Throughput Protein-Nucleic Acid Interaction Assay Based on Protein-Induced Fluorescence Enhancement.
Sign Up to like & getrecommendations! Published in 2021 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-0935-4_7
Abstract: Molecular processes involved in gene expression encompass multitudes of interactions between proteins and nucleic acids. Quantitative description of these interactions is crucial for delineating the mechanisms governing transcription, genome duplication, and translation. Here we describe… read more here.
Keywords: protein; protein nucleic; based protein; protein induced ... See more keywords
A quantitative characterization of interaction between prion protein with nucleic acids
Sign Up to like & getrecommendations! Published in 2018 at "Biochemistry and Biophysics Reports"
DOI: 10.1016/j.bbrep.2018.04.006
Abstract: Binding of recombinant prion protein with small highly structured RNAs, prokaryotic and eukaryotic prion protein mRNA pseudoknots, tRNA and polyA has been studied by the change in fluorescence anisotropy of the intrinsic tryptophan groups of… read more here.
Keywords: protein nucleic; nucleic acids; prion; prion protein ... See more keywords
Polymersomes for therapeutic delivery of protein and nucleic acid macromolecules: From design to therapeutic applications.
Sign Up to like & getrecommendations! Published in 2020 at "Biomacromolecules"
DOI: 10.1021/acs.biomac.9b01754
Abstract: Macromolecule-based therapeutic agents, particularly proteins, antigens, monoclonal antibodies, transcription factors, nucleic acids, and gene editing enzymes, have the potential to offer cures for previously untreatable diseases. However, they present an enormous delivery challenge due to… read more here.
Keywords: protein nucleic; delivery; therapeutic delivery; polymersomes therapeutic ... See more keywords
Halogen bonds in Protein-Nucleic Acid recognition.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of chemical theory and computation"
DOI: 10.1021/acs.jctc.0c00431
Abstract: Identifying new binding forces between electron donor and acceptor entities is key to properly understand molecular recognition and aggregation phenomena, which are of inmense importance to biology. For decades, the halogenation of DNA/RNA bases has… read more here.
Keywords: protein nucleic; recognition; halogen; bonds protein ... See more keywords
Cellular Delivery of Large Functional Proteins and Protein-Nucleic Acid Constructs via Localized Electroporation.
Sign Up to like & getrecommendations! Published in 2023 at "Nano letters"
DOI: 10.1021/acs.nanolett.2c04374
Abstract: Delivery of proteins and protein-nucleic acid constructs into live cells enables a wide range of applications from gene editing to cell-based therapies and intracellular sensing. However, electroporation-based protein delivery remains challenging due to the large… read more here.
Keywords: electroporation; localized electroporation; protein nucleic; nucleic acid ... See more keywords
Martini bead form factors for nucleic acids and their application in the refinement of protein–nucleic acid complexes against SAXS data
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Applied Crystallography"
DOI: 10.1107/s1600576719002450
Abstract: The use of small-angle X-ray scattering (SAXS) in combination with molecular dynamics simulation is hampered by its heavy computational cost. The calculation of SAXS from atomic structures can be speeded up by using a coarse-grain… read more here.
Keywords: nucleic acids; bead form; form factors; protein nucleic ... See more keywords
InPrNa: A Tool for Insight Into Protein–Nucleic Acids Interaction Information
Sign Up to like & getrecommendations! Published in 2019 at "IEEE Access"
DOI: 10.1109/access.2019.2943748
Abstract: Protein-nucleic acids bindings play key roles in many biological processes. However, the biological mechanisms underlying these interactions are not fully understood. Understanding the interface features between protein and nucleic acids may offer insights into how… read more here.
Keywords: protein nucleic; nucleic acids; inprna tool;