Protein S-palmitoylation is responsive to external signals and plays a regulatory role in microneme secretion in Plasmodium falciparum merozoites.
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DOI: 10.1021/acsinfecdis.9b00321
Abstract: Protein S-palmitoylation is an important post-translational modification (PTM) in blood stages of the malaria parasite, Plasmodium falciparum. S-palmitoylation refers to reversible covalent modification of cysteine residues of proteins by saturated fatty acids. In vivo, palmitoylation… read more here.
Keywords: protein palmitoylation; palmitoylation; chemistry; microneme secretion ... See more keywords
Protein S-palmitoylation in immunity
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DOI: 10.1098/rsob.200411
Abstract: S-palmitoylation is a reversible posttranslational lipid modification of proteins. It controls protein activity, stability, trafficking and protein–protein interactions. Recent global profiling of immune cells and targeted analysis have identified many S-palmitoylated immunity-associated proteins. Here, we… read more here.
Keywords: protein; palmitoylation; palmitoylation immunity; biology ... See more keywords
Protein S-palmitoylation regulates different stages of meiosis in Schizosaccharomyces pombe
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DOI: 10.26508/lsa.202201755
Abstract: The vital role of S-palmitoylation in cell differentiation is demonstrated in the fission yeast by showing that the modification is required at multiple meiotic stages including mating and karyogamy. Posttranslational protein S-palmitoylation regulates the localization… read more here.
Keywords: erf2 erf4; schizosaccharomyces pombe; protein palmitoylation; palmitoylation ... See more keywords
Protein Palmitoylation Modification During Viral Infection and Detection Methods of Palmitoylated Proteins
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cellular and Infection Microbiology"
DOI: 10.3389/fcimb.2022.821596
Abstract: Protein palmitoylation—a lipid modification in which one or more cysteine thiols on a substrate protein are modified to form a thioester with a palmitoyl group—is a significant post-translational biological process. This process regulates the trafficking,… read more here.
Keywords: viral infection; palmitoylation modification; protein palmitoylation; palmitoylation ... See more keywords
Protein Palmitoylation and Its Role in Bacterial and Viral Infections
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DOI: 10.3389/fimmu.2017.02003
Abstract: S-palmitoylation is a reversible, enzymatic posttranslational modification of proteins in which palmitoyl chain is attached to a cysteine residue via a thioester linkage. S-palmitoylation determines the functioning of proteins by affecting their association with membranes,… read more here.
Keywords: role bacterial; palmitoylation; palmitoylation role; role ... See more keywords
Insights Into Protein S-Palmitoylation in Synaptic Plasticity and Neurological Disorders: Potential and Limitations of Methods for Detection and Analysis
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Molecular Neuroscience"
DOI: 10.3389/fnmol.2018.00175
Abstract: S-palmitoylation (S-PALM) is a lipid modification that involves the linkage of a fatty acid chain to cysteine residues of the substrate protein. This common posttranslational modification (PTM) is unique among other lipid modifications because of… read more here.
Keywords: palmitoylation; detection; palmitoylation synaptic; protein palmitoylation ... See more keywords
Chemical probe mediated visualization of protein S-palmitoylation in patient tissue samples
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Physiology"
DOI: 10.3389/fphys.2023.1063247
Abstract: While protein palmitoylation has been studied for decades, our understanding of its clinical importance is minimal compared to other post translational modifications. As a result of the inherent challenges preventing the production of antibodies to… read more here.
Keywords: abe assay; palmitoylated proteins; protein palmitoylation; palmitoylation ... See more keywords
Putative Role of Protein Palmitoylation in Cardiac Lipid-Induced Insulin Resistance
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DOI: 10.3390/ijms21249438
Abstract: In the heart, inhibition of the insulin cascade following lipid overload is strongly associated with contractile dysfunction. The translocation of fatty acid transporter CD36 (SR-B2) from intracellular stores to the cell surface is a hallmark… read more here.
Keywords: lipid induced; protein palmitoylation; palmitoylation; insulin resistance ... See more keywords
Emerging roles of protein palmitoylation and its modifying enzymes in cancer cell signal transduction and cancer therapy
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DOI: 10.7150/ijbs.72244
Abstract: Protein palmitoylation is an increasingly investigated form of post-translational lipid modification that affects protein localization, accumulation, secretion and function. Recently, emerging findings have revealed that protein palmitoylation is crucial for many tumor-related signaling pathways, such… read more here.
Keywords: palmitoylation modifying; roles protein; modifying enzymes; protein palmitoylation ... See more keywords