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Published in 2022 at "Journal of pharmaceutical sciences"
DOI: 10.1016/j.xphs.2022.01.035
Abstract: Peristaltic pumping can cause protein particle formation. The expected causes were unfolding by heat in the pump head, oxidative stress by cavitation generated during roller movement, interfacial adsorption to the tubing wall and mechanical stress…
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Keywords:
particle formation;
peristaltic pumping;
protein particle;
particle ... See more keywords
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2
Published in 2023 at "AAPS PharmSciTech"
DOI: 10.1208/s12249-023-02561-4
Abstract: Polysorbates (PS) are nonionic surfactants that are commonly included in protein formulations to mitigate the formation of interfacial stress-induced protein particles and thus increase their long-term storage stability. Nonetheless, factors that dictate the efficiency of…
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Keywords:
stress;
particle formation;
interfacial dilatational;
protein particle ... See more keywords