Synthesis and Applications of Protein/Peptide‐Polymer Conjugates
Sign Up to like & getrecommendations! Published in 2017 at "Macromolecular Chemistry and Physics"
DOI: 10.1002/macp.201600595
Abstract: Recent advances in synthetic methodologies have brought us closer than ever to the precision conferred by nature. For example, the control possible in reversible deactivation radical polymerization enables us to design and synthesize macromolecules with… read more here.
Keywords: applications protein; polymer conjugates; peptide polymer; polymer ... See more keywords
The Utility of Nanopore Technology for Protein and Peptide Sensing
Sign Up to like & getrecommendations! Published in 2018 at "PROTEOMICS"
DOI: 10.1002/pmic.201800026
Abstract: Resistive pulse nanopore sensing enables label‐free single‐molecule analysis of a wide range of analytes. An increasing number of studies have demonstrated the feasibility and usefulness of nanopore sensing for protein and peptide characterization. Nanopores offer… read more here.
Keywords: protein; nanopore technology; technology protein; peptide sensing ... See more keywords
Peptide Suboptimal Conformation Sampling for the Prediction of Protein-Peptide Interactions.
Sign Up to like & getrecommendations! Published in 2017 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-6798-8_3
Abstract: The blind identification of candidate patches of interaction on the protein surface is a difficult task that can hardly be accomplished without a heuristic or the use of simplified representations to speed up the search.… read more here.
Keywords: protein; suboptimal conformation; peptide suboptimal; conformation sampling ... See more keywords
Protein-peptide docking: opportunities and challenges.
Sign Up to like & getrecommendations! Published in 2018 at "Drug discovery today"
DOI: 10.1016/j.drudis.2018.05.006
Abstract: Peptides have recently attracted much attention as promising drug candidates. Rational design of peptide-derived therapeutics usually requires structural characterization of the underlying protein-peptide interaction. Given that experimental characterization can be difficult, reliable computational tools are… read more here.
Keywords: drug; docking opportunities; opportunities challenges; peptide docking ... See more keywords
Computational avenues in oral protein and peptide therapeutics.
Sign Up to like & getrecommendations! Published in 2021 at "Drug discovery today"
DOI: 10.1016/j.drudis.2021.03.003
Abstract: Proteins and peptides are amongst the most sought-after biomolecules because of their exceptional potential to cater to a vast range of diseases. Although widely studied and researched, the oral delivery of these biomolecules remains a… read more here.
Keywords: avenues oral; computational avenues; oral protein; peptide therapeutics ... See more keywords
Sustained Release Systems for Delivery of Therapeutic Peptide/Protein.
Sign Up to like & getrecommendations! Published in 2021 at "Biomacromolecules"
DOI: 10.1021/acs.biomac.1c00160
Abstract: Peptide/protein therapeutics have been significantly applied in the clinical treatment of various diseases such as cancer, diabetes, etc. owing to their high biocompatibility, specificity, and therapeutic efficacy. However, due to their immunogenicity, instability stemming from… read more here.
Keywords: protein; peptide protein; release systems; sustained release ... See more keywords
Marine Fish Protein Peptide Regulating Potassium Oxonate-Induced Intestinal Dysfunction in Hyperuricemia Rats Helps Alleviate Kidney Inflammation.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.2c04017
Abstract: The metabolic disease hyperuricemia (HUA) is characterized by a disturbance in purine metabolism. Peptides, such as marine fish-derived peptides, have previously been shown to be effective in alleviating HUA. In this study, HUA rats were… read more here.
Keywords: protein peptide; marine fish; fish protein; kidney ... See more keywords
Improving Protein-Peptide Docking Results via Pose-Clustering and Rescoring with a Combined Knowledge-Based and MM-GBSA Scoring Function
Sign Up to like & getrecommendations! Published in 2020 at "Journal of chemical information and modeling"
DOI: 10.1021/acs.jcim.0c00058
Abstract: Protein-peptide docking, which predicts the complex structure between a protein and a peptide, is a valuable computational tool in peptide therapeutics development and mechanistic investigation of peptides involved cellular processes. Although current peptide docking approaches… read more here.
Keywords: knowledge based; scoring function; post docking; peptide docking ... See more keywords
Predicting Protein-Peptide Complex Structures by Accounting for Peptide Flexibility and the Physicochemical Environment
Sign Up to like & getrecommendations! Published in 2022 at "Journal of chemical information and modeling"
DOI: 10.1021/acs.jcim.1c00836
Abstract: Predicting protein-peptide complex structures is crucial to the understanding of a vast variety of peptide-mediated cellular processes and to peptide-based drug development. Peptide flexibility and binding mode ranking are the two major challenges for protein-peptide… read more here.
Keywords: peptide; protein peptide; predicting protein; peptide complex ... See more keywords
Simultaneous Prediction of Interaction Sites on the Protein and Peptide Sides of Complexes through Multilayer Graph Convolutional Networks
Sign Up to like & getrecommendations! Published in 2023 at "Journal of chemical information and modeling"
DOI: 10.1021/acs.jcim.3c00192
Abstract: Identifying the binding residues of protein-peptide complexes is essential for understanding protein function mechanisms and exploring drug discovery. Recently, many computational methods have been developed to predict the interaction sites of either protein or peptide.… read more here.
Keywords: protein peptide; sites protein; interaction sites; peptide sides ... See more keywords
Predicting Protein-Peptide Interactions: Benchmarking Deep Learning Techniques and a Comparison with Focused Docking.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of chemical information and modeling"
DOI: 10.1021/acs.jcim.3c00602
Abstract: The accurate prediction of protein structures achieved by deep learning (DL) methods is a significant milestone and has deeply impacted structural biology. Shortly after its release, AlphaFold2 has been evaluated for predicting protein-peptide interactions and… read more here.
Keywords: interactions benchmarking; predicting protein; protein peptide; peptide interactions ... See more keywords