Aggregation or phase separation can be induced in highly charged proteins by small charged biomolecules.
Sign Up to like & getrecommendations! Published in 2022 at "Soft matter"
DOI: 10.1039/d2sm00384h
Abstract: Protein phase separation in biological systems has captured the attention of scientists in the last decade; however, the main mechanism underlying protein phase separation in cells remains unclear. Biologists, physicists, and chemists have all tried… read more here.
Keywords: protein phase; highly charged; charged biomolecules; separation ... See more keywords
DAmFRET measures saturating concentrations and toxicities of protein phase transitions in vivo.
Sign Up to like & getrecommendations! Published in 2023 at "Molecular biology of the cell"
DOI: 10.1091/mbc.e22-11-0503
Abstract: Protein phase transitions broadly govern protein function and dysfunction. However, analyzing the consequences of specific phase transitions in cells is hindered by the low throughput and limited resolution of fluorescence microscopy, and this problem is… read more here.
Keywords: measures saturating; phase transitions; saturating concentrations; concentrations toxicities ... See more keywords
Protein phase separation: A novel therapy for cancer?
Sign Up to like & getrecommendations! Published in 2020 at "British Journal of Pharmacology"
DOI: 10.1111/bph.15242
Abstract: In recent years, phase separation has been increasingly reported to play a pivotal role in a wide range of biological processes. Due to the close relationships between cancer and disorders in intracellular physiological function, the… read more here.
Keywords: phase separation; therapy; protein phase; separation ... See more keywords
An Interpretable Machine-Learning Algorithm to Predict Disordered Protein Phase Separation Based on Biophysical Interactions
Sign Up to like & getrecommendations! Published in 2022 at "Biomolecules"
DOI: 10.3390/biom12081131
Abstract: Protein phase separation is increasingly understood to be an important mechanism of biological organization and biomaterial formation. Intrinsically disordered protein regions (IDRs) are often significant drivers of protein phase separation. A number of protein phase… read more here.
Keywords: biophysical interactions; phase separation; protein phase; disordered protein ... See more keywords
Protein Phase Separation: New Insights into Carcinogenesis
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DOI: 10.3390/cancers14235971
Abstract: Simple Summary The global burden of cancer is substantial and growing. Among 22 groups of diseases and injuries in the GBD 2019 study, cancer was second only to cardiovascular diseases for the number of deaths… read more here.
Keywords: phase separation; separation new; protein phase; separation ... See more keywords
Protein phase separation: new insights into cell division.
Sign Up to like & getrecommendations! Published in 2023 at "Acta biochimica et biophysica Sinica"
DOI: 10.3724/abbs.2023093
Abstract: As the foundation for the development of multicellular organisms and the self-renewal of single cells, cell division is a highly organized event which segregates cellular components into two daughter cells equally or unequally, thus producing… read more here.
Keywords: division; cell division; phase separation; protein phase ... See more keywords