Okadaic acid promotes epithelial‐mesenchymal transition of hepatocellular carcinoma cells by inhibiting protein phosphatase 2A
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.29629
Abstract: As a specific inhibitor of serine/threonine protein phosphatases, okadaic acid (OA) has been found to be a tumor promoter. However, whether OA plays a role in metastasis of hepatocellular carcinoma (HCC) has not been well… read more here.
Keywords: hepatocellular carcinoma; mesenchymal transition; cells inhibiting; epithelial mesenchymal ... See more keywords
Glc8, a regulator of protein phosphatase type 1, mediates oxidation tolerance, asexual development and virulence in Beauveria bassiana, a filamentous entomopathogenic fungus
Sign Up to like & getrecommendations! Published in 2018 at "Current Genetics"
DOI: 10.1007/s00294-018-0876-y
Abstract: Protein phosphatase type 1 (PP1) plays an important role in cellular metabolism and development in yeast. In PP1 enzyme complex, Glc8 protein is a global regulatory subunit and regulates many physiological processes. However, its biological… read more here.
Keywords: protein; bbglc8; virulence; phosphatase type ... See more keywords
Differential regulation of protein phosphatase 1 (PP1) isoforms in human heart failure and atrial fibrillation
Sign Up to like & getrecommendations! Published in 2017 at "Basic Research in Cardiology"
DOI: 10.1007/s00395-017-0635-0
Abstract: Protein phosphatase 1 (PP1) is a key regulator of important cardiac signaling pathways. Dysregulation of PP1 has been heavily implicated in cardiac dysfunctions. Accordingly, pharmacological targeting of PP1 activity is considered for therapeutic intervention in… read more here.
Keywords: pp1 isoforms; heart; pp1; phosphatase pp1 ... See more keywords
Control of cell migration by the novel protein phosphatase-2A interacting protein inka2
Sign Up to like & getrecommendations! Published in 2020 at "Cell and Tissue Research"
DOI: 10.1007/s00441-020-03169-x
Abstract: Cell migration is essential for many physiological and pathological processes, including embryonic development, wound healing, immune response and cancer metastasis. Inka2 transcripts are observed in migrating cells during embryonic development, suggesting the involvement of inka2… read more here.
Keywords: inka2; cell migration; pp2a; migration ... See more keywords
Glucohexaose-induced protein phosphatase 2C regulates cell redox status of cucumber seedling
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Biosciences"
DOI: 10.1007/s12038-018-9738-5
Abstract: Protein Phosphatase 2C (PP2C) is an important phosphatase-like protein in eukaryotic organisms that can negatively regulate protein kinase cascade abscisic acid (ABA) signal system through phosphorylation and carry out vital roles in various cell processes.… read more here.
Keywords: cell redox; protein phosphatase; redox status; glucohexaose induced ... See more keywords
Dual phosphorylation of protein phosphatase PPM1H promotes dephosphorylation of Smad1 in cellulo.
Sign Up to like & getrecommendations! Published in 2020 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2020.05.082
Abstract: Protein phosphatase PPM1H is known to participate in various biological or pathophysiological mechanisms. However, little is known about the molecular mechanisms of its regulation. In this study, we investigated the protein kinases that directly phosphorylate… read more here.
Keywords: protein; phosphatase ppm1h; ser 210; phosphorylation ... See more keywords
Phosphatase magnesium-dependent 1 δ (PPM1D), serine/threonine protein phosphatase and novel pharmacological target in cancer.
Sign Up to like & getrecommendations! Published in 2020 at "Biochemical pharmacology"
DOI: 10.1016/j.bcp.2020.114362
Abstract: Aberrations in DNA damage response genes are recognized mediators of tumorigenesis and resistance to chemo- and radiotherapy. While protein phosphatase magnesium-dependent 1 δ (PPM1D), located on the long arm of chromosome 17 at 17q22-23, is… read more here.
Keywords: magnesium dependent; phosphatase; phosphatase magnesium; ppm1d ... See more keywords
PPP2R5A: A multirole protein phosphatase subunit in regulating cancer development.
Sign Up to like & getrecommendations! Published in 2018 at "Cancer letters"
DOI: 10.1016/j.canlet.2017.11.024
Abstract: Protein phosphatase 2, regulatory subunit B (B56), alpha isoform (PPP2R5A) is one of the regulatory subunits of the protein phosphatase 2A (PP2A), which is a major member of protein serine/threonine phosphatases in cells. PPP2R5A can regulate the… read more here.
Keywords: protein; ppp2r5a; cancer; subunit ... See more keywords
Complex functionality of protein phosphatase 1 isoforms in the heart.
Sign Up to like & getrecommendations! Published in 2021 at "Cellular signalling"
DOI: 10.1016/j.cellsig.2021.110059
Abstract: Protein phosphatase 1(PP1) is a key regulator of cardiac function through dephosphorylating serine/threonine residues within target proteins to oppose the function of protein kinases. Studies from failing hearts of animal models and human patients have… read more here.
Keywords: protein; complex functionality; heart; pp1 ... See more keywords
The serine/threonine protein phosphatase 2A controls autoimmunity.
Sign Up to like & getrecommendations! Published in 2018 at "Clinical immunology"
DOI: 10.1016/j.clim.2017.07.012
Abstract: Protein phosphatase 2A (PP2A) is the first serine/threonine phosphatase recognized to contribute to human and murine lupus immunopathology. PP2A expression in SLE is controlled both epigenetically and genetically, and it is increased in patients with… read more here.
Keywords: threonine protein; serine threonine; phosphatase; protein phosphatase ... See more keywords
Salicylic Acid Targets Protein Phosphatase 2A to Attenuate Growth in Plants
Sign Up to like & getrecommendations! Published in 2020 at "Current Biology"
DOI: 10.1016/j.cub.2019.11.058
Abstract: Summary Plants, like other multicellular organisms, survive through a delicate balance between growth and defense against pathogens. Salicylic acid (SA) is a major defense signal in plants, and the perception mechanism as well as downstream… read more here.
Keywords: salicylic acid; acid targets; phosphatase attenuate; targets protein ... See more keywords