The logic of protein post‐translational modifications (PTMs): Chemistry, mechanisms and evolution of protein regulation through covalent attachments
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DOI: 10.1002/bies.202300178
Abstract: Protein post‐translational modifications (PTMs) play a crucial role in all cellular functions by regulating protein activity, interactions and half‐life. Despite the enormous diversity of modifications, various PTM systems show parallels in their chemical and catalytic… read more here.
Keywords: chemistry; translational modifications; protein post; logic ... See more keywords
Selective Protein (Post-)modifications through Dynamic Covalent Chemistry: Self-activated SNAr Reactions.
Sign Up to like & getrecommendations! Published in 2025 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.4c15421
Abstract: SNAr reactions were remarkably accelerated using a pretargeting and activating unit based on dynamic covalent chemistry (DCvC). A Cys attack at the C-F bond on the aromatic ring of salicylaldehyde derivatives was only observed upon… read more here.
Keywords: chemistry; covalent chemistry; selective protein; protein post ... See more keywords
Protein post-translational modifications in bacteria
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DOI: 10.1038/s41579-019-0243-0
Abstract: Over the past decade the number and variety of protein post-translational modifications that have been detected and characterized in bacteria have rapidly increased. Most post-translational protein modifications occur in a relatively low number of bacterial… read more here.
Keywords: protein post; translational modifications; post translational; modifications bacteria ... See more keywords
DIPG-16. THE BIG AND SMALL OF PROTEIN POST-TRANSLATIONAL MODIFICATIONS: TARGETING SUMOYLATION AND CITRULLINATION IN DIFFUSE MIDLINE GLIOMA
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DOI: 10.1093/neuonc/noae064.069
Abstract: Abstract BACKGROUND Protein post-translational modifications (PTMs) alter the properties of protein through proteolytic cleavage, or the addition of modifying groups to one or more amino acids. Histones are major targets of PTMs, including through SUMOylation… read more here.
Keywords: sumoylation; dmg; citrullination; protein post ... See more keywords
The ever-increasing necessity of mass spectrometry in dissecting protein post-translational modifications catalyzed by bacterial effectors.
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DOI: 10.1111/mmi.15071
Abstract: Protein post-translational modifications (PTMs), such as ADP-ribosylation and phosphorylation, regulate multiple fundamental biological processes in cells. During bacterial infection, effector proteins are delivered into host cells through dedicated bacterial secretion systems and can modulate important… read more here.
Keywords: translational modifications; post translational; protein post; bacterial effectors ... See more keywords
Editorial: Protein post-translational modifications in the nervous system: from development to disease and ageing
Sign Up to like & getrecommendations! Published in 2024 at "Frontiers in Molecular Neuroscience"
DOI: 10.3389/fnmol.2024.1501719
Abstract: Graphical Abstract PTMs are crucial for biological processes contributing to healthy organ function. Protein post-translational modifications (PTMs), such as phosphorylation (P), acetylation (Ac), SUMOylation (SUMO), S-nitrosylation (Nitro), ubiquitination (Ub) and glycosylation (Glyco), affect a wide… read more here.
Keywords: translational modifications; protein post; post translational; editorial protein ... See more keywords