The role of the proteasome in mitochondrial protein quality control.
Sign Up to like & getrecommendations! Published in 2023 at "IUBMB life"
DOI: 10.1002/iub.2734
Abstract: The abundance of each cellular protein is dynamically adjusted to the prevailing metabolic and stress conditions by modulation of their synthesis and degradation rates. The proteasome represents the major machinery for the degradation of proteins… read more here.
Keywords: protein quality; quality control; role; mitochondrial protein ... See more keywords
Protein quality control in the endoplasmic reticulum
Sign Up to like & getrecommendations! Published in 2020 at "Current Opinion in Cell Biology"
DOI: 10.1016/j.ceb.2020.04.002
Abstract: Summary Misfolded and mistargeted proteins in the early secretory pathway present significant risks to the cell. A diverse and integrated network of quality control pathways protects the cell from these threats. We focus on the… read more here.
Keywords: quality control; quality; endoplasmic reticulum; protein quality ... See more keywords
Protein quality as functional unit – A methodological framework for inclusion in life cycle assessment of food
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Cleaner Production"
DOI: 10.1016/j.jclepro.2016.06.115
Abstract: In order to. develop more sustainable food systems, there is a need to find methods that simultaneously consider environmental impacts and nutritional benefits. The purpose of this, study was to de ... read more here.
Keywords: unit methodological; functional unit; quality functional; methodological framework ... See more keywords
Arsenite Binds to ZNF598 to Perturb Ribosome-Associated Protein Quality Control.
Sign Up to like & getrecommendations! Published in 2020 at "Chemical research in toxicology"
DOI: 10.1021/acs.chemrestox.9b00412
Abstract: Arsenic pollution in drinking water is a widespread public health problem, and it affects approximately 200 million people in over 70 countries. Many human diseases, including neurodegenerative disorders, are engendered by the malfunction of proteins… read more here.
Keywords: associated protein; protein quality; quality control; ribosome associated ... See more keywords
Impact of Processing on the Protein Quality of Pinto Bean (Phaseolus vulgaris) and Buckwheat (Fagopyrum esculentum Moench) Flours and Blends, As Determined by in Vitro and in Vivo Methodologies.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.7b00697
Abstract: Blending of protein sources can increase protein quality by compensating for limiting amino acids present in individual sources, whereas processing grain flours by extrusion or baking can also alter protein quality. To determine the effect… read more here.
Keywords: protein; vitro vivo; buckwheat; protein quality ... See more keywords
Zinc regulates ERp44-dependent protein quality control in the early secretory pathway
Sign Up to like & getrecommendations! Published in 2019 at "Nature Communications"
DOI: 10.1038/s41467-019-08429-1
Abstract: Zinc ions (Zn2+) are imported into the early secretory pathway by Golgi-resident transporters, but their handling and functions are not fully understood. Here, we show that Zn2+ binds with high affinity to the pH-sensitive chaperone… read more here.
Keywords: secretory pathway; zn2; protein quality; early secretory ... See more keywords
DAXX represents a new type of protein-folding enabler.
Sign Up to like & getrecommendations! Published in 2021 at "Nature"
DOI: 10.1038/s41586-021-03824-5
Abstract: Protein quality control systems are crucial for cellular function and organismal health. At present, most known protein quality control systems are multicomponent machineries that operate via ATP-regulated interactions with non-native proteins to prevent aggregation and promote… read more here.
Keywords: protein; aggregation; protein folding; protein quality ... See more keywords
Synthetic protein quality control to enhance full-length translation in bacteria
Sign Up to like & getrecommendations! Published in 2021 at "Nature Chemical Biology"
DOI: 10.1038/s41589-021-00736-3
Abstract: Coupled transcription and translation processes in bacteria cause indiscriminate translation of intact and truncated messenger RNAs, inevitably generating nonfunctional polypeptides. Here, we devised a synthetic protein quality control (ProQC) system that enables translation only when… read more here.
Keywords: protein quality; synthetic protein; translation; full length ... See more keywords
Selection and evolution of disulfide-rich peptides via cellular protein quality control
Sign Up to like & getrecommendations! Published in 2023 at "Chemical Science"
DOI: 10.1039/d2sc05343h
Abstract: Disulfide-rich peptides (DRPs) are an interesting and promising molecular format for drug discovery and development. However, the engineering and application of DRPs rely on the foldability of the peptides into specific structures with correct disulfide… read more here.
Keywords: protein quality; quality control; rich peptides; disulfide rich ... See more keywords
It's not just a phase; ubiquitination in cytosolic protein quality control
Sign Up to like & getrecommendations! Published in 2021 at "Biochemical Society Transactions"
DOI: 10.1042/bst20200694
Abstract: The accumulation of misfolded proteins is associated with numerous degenerative conditions, cancers and genetic diseases. These pathological imbalances in protein homeostasis (termed proteostasis), result from the improper triage and disposal of damaged and defective proteins… read more here.
Keywords: control; protein quality; cytosolic protein; quality control ... See more keywords
Greater protein quality of an egg breakfast may be inadequate to induce satiety during weight loss, compared with a cereal breakfast of equal protein quantity
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Food Sciences and Nutrition"
DOI: 10.1080/09637486.2022.2133097
Abstract: Abstract We compared the effects of consuming egg-breakfast of superior protein quality to cereal-breakfast of similar energy density and protein quantity, but lower protein quality. Two, two-week randomised crossover clinical trials included 30 otherwise healthy… read more here.
Keywords: egg breakfast; protein quality; protein quantity; breakfast ... See more keywords