G-PROTEIN RECEPTOR KINASE 5 POLYMORPHISMS AND OUTCOMES IN THE AFRICAN AMERICAN HEART FAILURE TRIAL: RESULTS FROM THE GENETIC RISK ASSESSMENT OF HEART FAILURE IN AFRICAN-AMERICANS SUB-STUDY
Sign Up to like & getrecommendations! Published in 2017 at "Journal of the American College of Cardiology"
DOI: 10.1016/s0735-1097(17)34075-5
Abstract: Background: G-protein receptor kinases (GRKs) are central to beta receptor inactivation. A polymorphism for GRK5, common in African Americans, substitutes leucine (T allele) for glutamine (A allele) at amino acid 41. GRK5 Leu41 boosts beta… read more here.
Keywords: protein receptor; heart; african americans; heart failure ... See more keywords
Protein C receptor is a therapeutic stem cell target in a distinct group of breast cancers
Sign Up to like & getrecommendations! Published in 2019 at "Cell Research"
DOI: 10.1038/s41422-019-0225-9
Abstract: Breast cancer is a heterogeneous disease. In particular, triple-negative breast cancer (TNBC) comprises various molecular subgroups with unclear identities and currently has few targeted treatment options. Our previous study identified protein C receptor (Procr) as… read more here.
Keywords: protein receptor; breast; breast cancers; tnbc ... See more keywords
One amino acid in mouse activated factor VII defines its endothelial protein C receptor (EPCR) binding and modulates its EPCR‐dependent hemostatic activity in vivo
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Thrombosis and Haemostasis"
DOI: 10.1111/jth.13607
Abstract: Essentials The lack of factor (F) VIIa‐endothelial protein C receptor (EPCR) binding in mice is unresolved. A single substitution of Leu4 to Phe in mouse FVIIa (mFVIIa) enables its interaction with EPCR. mFVIIa with a… read more here.
Keywords: epcr binding; protein receptor; receptor epcr; endothelial protein ... See more keywords
Turning on a G protein receptor
Sign Up to like & getrecommendations! Published in 2019 at "Science"
DOI: 10.1126/science.364.6442.747-c
Abstract: Signal Transduction The mammalian target of rapamycin complex 1 (mTORC1) protein kinase is activated at the lysosomal membrane and helps control autophagy and metabolism. It interacts with other proteins that act as sensors for stimuli… read more here.
Keywords: protein receptor; receptor; turning protein; protein ... See more keywords
Evidences of G-Coupled Protein Receptor (GPCR) signaling in the human malaria parasite Plasmodium falciparum for sensing its microenvironment and the role of purinergic signaling in malaria parasites..
Sign Up to like & getrecommendations! Published in 2020 at "Current topics in medicinal chemistry"
DOI: 10.2174/1568026620666200826122716
Abstract: The nucleotides were discovered in the early 19th century and a few years later the role of such molecules in the energy metabolism and cell survival was postulated. In 1972 a pioneer work by Burnstock… read more here.
Keywords: protein receptor; evidences coupled; receptor gpcr; gpcr signaling ... See more keywords
Characterization of the C6D7-RBD Human Monoclonal Antibody Specific to the SARS-CoV-2 S Protein Receptor-Binding Domain
Sign Up to like & getrecommendations! Published in 2023 at "Acta Naturae"
DOI: 10.32607/actanaturae.11849
Abstract: The new coronavirus infection COVID-19 is an acute viral disease that affects primarily the upper respiratory tract. The etiological agent of COVID-19 is the SARS-CoV-2 RNA virus (Coronaviridae family, Betacoronavirus genus, Sarbecovirus subgenus). We have… read more here.
Keywords: c6d7 rbd; monoclonal antibody; rbd; protein receptor ... See more keywords
Adeno-associated virus receptor complexes and implications for adeno-associated virus immune neutralization
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2023.1116896
Abstract: Adeno-associated viruses (AAV) are among the foremost vectors for in vivo gene therapy. A number of monoclonal antibodies against several serotypes of AAV have previously been prepared. Many are neutralizing, and the predominant mechanisms have… read more here.
Keywords: protein receptor; associated virus; neutralization; adeno associated ... See more keywords