An intrinsically disordered protein region encoded by the human disease gene CLEC16A regulates mitophagy
Sign Up to like & getrecommendations! Published in 2022 at "Autophagy"
DOI: 10.1080/15548627.2022.2080383
Abstract: ABSTRACT CLEC16A regulates mitochondrial health through mitophagy and is associated with over 20 human diseases. However, the key structural and functional regions of CLEC16A, and their relevance for human disease, remain unknown. Here, we report… read more here.
Keywords: intrinsically disordered; human disease; protein region; clec16a ... See more keywords
Recombination events are concentrated in the spike protein region of Betacoronaviruses.
Sign Up to like & getrecommendations! Published in 2020 at "PLoS genetics"
DOI: 10.1371/journal.pgen.1009272
Abstract: The Betacoronaviruses comprise multiple subgenera whose members have been implicated in human disease. As with SARS, MERS and now SAR-CoV-2, the origin and emergence of new variants are often attributed to events of recombination that… read more here.
Keywords: protein region; recombination events; concentrated spike; spike protein ... See more keywords
SARS-CoV-2 Epitope Mapping on Microarrays Highlights Strong Immune-Response to N Protein Region
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DOI: 10.3390/vaccines9010035
Abstract: A workflow for rapid SARS-CoV-2 epitope discovery on peptide microarrays is herein reported. The process started with a proteome-wide screening of immunoreactivity based on the use of a high-density microarray followed by a refinement and… read more here.
Keywords: protein; protein region; cov epitope; sars cov ... See more keywords