Predicting Protein-Protein Interfaces that Bind Intrinsically Disordered Protein Regions.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of molecular biology"
DOI: 10.1016/j.jmb.2019.06.010
Abstract: A long-standing goal in biology is the complete annotation of function and structure on all protein-protein interactions, a large fraction of which is mediated by intrinsically disordered protein regions (IDRs). However, our knowledge base of… read more here.
Keywords: protein; protein protein; biology; protein regions ... See more keywords
How do intrinsically disordered protein regions encode a driving force for liquid-liquid phase separation?
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DOI: 10.1016/j.sbi.2020.09.004
Abstract: Liquid-liquid phase separation is the mechanism underlying the formation of biomolecular condensates. Disordered protein regions often drive phase separation, but molecular interactions of disordered protein regions are not well understood, sometimes leading to the conflation… read more here.
Keywords: phase separation; phase; liquid; protein regions ... See more keywords
Theater in the Self-Cleaning Cell: Intrinsically Disordered Proteins or Protein Regions Acting with Membranes in Autophagy
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DOI: 10.3390/membranes12050457
Abstract: Intrinsically disordered proteins and protein regions (IDPs/IDPRs) are mainly involved in signaling pathways, where fast regulation, temporal interactions, promiscuous interactions, and assemblies of structurally diverse components including membranes are essential. The autophagy pathway builds, de… read more here.
Keywords: theater self; intrinsically disordered; disordered proteins; protein regions ... See more keywords