IRE1α nucleotide sequence cleavage specificity in the unfolded protein response
Sign Up to like & getrecommendations! Published in 2017 at "FEBS Letters"
DOI: 10.1002/1873-3468.12546
Abstract: Inositol‐requiring enzyme 1 (IRE1) is a conserved sensor of the unfolded protein response that has protein kinase and endoribonuclease (RNase) enzymatic activities and thereby initiates HAC1/XBP1 splicing. Previous studies demonstrated that human IRE1α (hIRE1α) does… read more here.
Keywords: cleavage; unfolded protein; protein response; cleavage specificity ... See more keywords
Inhibiting the IRE1α Axis of the Unfolded Protein Response Enhances the Antitumor Effect of AZD1775 in TP53 Mutant Ovarian Cancer
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Science"
DOI: 10.1002/advs.202105469
Abstract: Targeting the G2/M checkpoint mediator WEE1 has been explored as a novel treatment strategy in ovarian cancer, but mechanisms underlying its efficacy and resistance remains to be understood. Here, it is demonstrated that the WEE1… read more here.
Keywords: tp53 mutant; unfolded protein; ovarian cancer; protein response ... See more keywords
Perfluorooctanoic acid activates the unfolded protein response in pancreatic acinar cells
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.22561
Abstract: Perfluoroalkyl substances, such as perfluorooctanoic acid (PFOA), are widely used in consumer and industrial applications. Human epidemiologic and animal studies suggest that PFOA exposure elicits adverse effects on the pancreas; however, little is known about… read more here.
Keywords: perfluorooctanoic acid; pancreatic acinar; pfoa; unfolded protein ... See more keywords
Vitexin prevents Aβ proteotoxicity in transgenic Caenorhabditis elegans model of Alzheimer's disease by modulating unfolded protein response
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.22632
Abstract: Alzheimer's disease (AD) accounts for an estimated 60% to 80% of all dementia cases. The present study is aimed at evaluating the neuroprotective efficacy of vitexin, an apigenin flavone glycoside using transgenic Caenorhabditis elegans strain… read more here.
Keywords: vitexin; unfolded protein; alzheimer disease; protein response ... See more keywords
MicroRNA‐382 silencing induces a mitonuclear protein imbalance and activates the mitochondrial unfolded protein response in muscle cells
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.27401
Abstract: Proper mitochondrial function plays a central role in cellular metabolism. Various diseases as well as aging are associated with diminished mitochondrial function. Previously, we identified 19 miRNAs putatively involved in the regulation of mitochondrial metabolism… read more here.
Keywords: imbalance; unfolded protein; muscle; protein response ... See more keywords
The role and mechanism of unfolded protein response signaling pathway in methylmercury‐induced apoptosis of mouse spermatocytes germ cell‐2 cells
Sign Up to like & getrecommendations! Published in 2022 at "Environmental Toxicology"
DOI: 10.1002/tox.23684
Abstract: The study aimed to explore the role and mechanism of unfolded protein response (UPR) in methylmercury (MeHg)‐induced Mouse Spermatocytes (GC‐2spd[ts]) apoptosis. Methods such as MTT, flow cytometry, and Western Blot were used to evaluate the… read more here.
Keywords: cell; unfolded protein; apoptosis; mechanism unfolded ... See more keywords
Detection of Unfolded Protein Response by Polymerase Chain Reaction.
Sign Up to like & getrecommendations! Published in 2021 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-1162-3_2
Abstract: The unfolded protein response is a cellular adaptive mechanism localized in the endoplasmic reticulum. It involves three phases: the detection of increased presence of unfolded proteins as a result of cellular stressors; the execution of… read more here.
Keywords: unfolded protein; protein response; response polymerase; detection unfolded ... See more keywords
Nicotiana benthamiana NbbZIP28, a possible regulator of unfolded protein response, plays a negative role in viral infection
Sign Up to like & getrecommendations! Published in 2017 at "European Journal of Plant Pathology"
DOI: 10.1007/s10658-017-1231-8
Abstract: The unfolded protein response (UPR), a highly conserved cellular defense pathway, is activated by endoplasmic reticulum (ER) stress. In Arabidopsis, the transcription factor AtbZIP28 mediates ER stress responses induced by tunicamycin. Here, we identified NbbZIP28… read more here.
Keywords: nbbzip28; response; unfolded protein; protein response ... See more keywords
A Novel Animal Model for Studying Depression Featuring the Induction of the Unfolded Protein Response in Hippocampus
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Neurobiology"
DOI: 10.1007/s12035-019-01687-6
Abstract: Depression is the leading cause of disability worldwide with global distribution of 322 million people suffering from the disease. While much is understood about depression, the underlying pathophysiology is yet to be fully characterized. Recently,… read more here.
Keywords: depression; response; unfolded protein; protein response ... See more keywords
PRRT2 inhibits the proliferation of glioma cells by modulating unfolded protein response pathway.
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2017.02.052
Abstract: Accumulating studies reported mutations in the gene encoding the proline-rich transmembrane protein 2 (PRRT2) to be causative for several paroxysmal neurological disorders, including paroxysmal kinesigenic dyskinesia (PKD), PKD combined with infantile seizures (ICCA), and benign… read more here.
Keywords: protein; unfolded protein; protein response; pathway ... See more keywords
The unfolded protein response and the biology of uveal melanoma.
Sign Up to like & getrecommendations! Published in 2022 at "Biochimie"
DOI: 10.1016/j.biochi.2022.01.017
Abstract: Uveal melanoma (UM) is a highly metastatic ocular cancer that arises from the melanocytes of the uveal tract (the choroid, ciliary body and iris). Despite a growing understanding of UM biology, effective systemic treatments are… read more here.
Keywords: protein response; biology; uveal melanoma; unfolded protein ... See more keywords