Disulfiram Oxy-Derivatives Suppress Protein Retrotranslocation across the ER Membrane to the Cytosol and Initiate Paraptosis-like Cell Death
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DOI: 10.3390/membranes12090845
Abstract: Disulfiram (DSF) and its derivatives were here investigated as antineoplastic agents, and their important feature is the ability to influence the UPS. We have recently shown that hydroxocobalamin catalyzes the aerobic oxidation of diethyldithiocarbamate to… read more here.
Keywords: paraptosis like; protein retrotranslocation; oxy derivatives; cell death ... See more keywords