Evolution avoids a pathological stabilizing interaction in the immune protein S100A9
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2208029119
Abstract: Stability constrains evolution. While much is known about constraints on destabilizing mutations, less is known about the constraints on stabilizing mutations. We recently identified a mutation in the innate immune protein S100A9 that provides insight… read more here.
Keywords: interaction; stabilizing mutations; protein s100a9; protein ... See more keywords