Inhibition of nonstructural protein 15 of SARS‐CoV‐2 by golden spice: A computational insight
Sign Up to like & getrecommendations! Published in 2022 at "Cell Biochemistry and Function"
DOI: 10.1002/cbf.3753
Abstract: The quick widespread of the coronavirus and speedy upsurge in the tally of cases demand the fast development of effective drugs. The uridine‐directed endoribonuclease activity of nonstructural protein 15 (Nsp15) of the coronavirus is responsible… read more here.
Keywords: protein sars; nonstructural protein; inhibition nonstructural; sars cov ... See more keywords
Nucleocapsid protein of SARS‐CoV‐2 is a potential target for developing new generation of vaccine
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Clinical Laboratory Analysis"
DOI: 10.1002/jcla.24479
Abstract: SARS‐CoV‐2 has spread worldwide causing more than 400 million people with virus infections since early 2020. Currently, the existing vaccines targeting the spike glycoprotein (S protein) of SARS‐CoV‐2 are facing great challenge from the infection… read more here.
Keywords: nucleocapsid protein; developing new; new generation; protein sars ... See more keywords
Molecular basis for drug repurposing to study the interface of the S protein in SARS-CoV-2 and human ACE2 through docking, characterization, and molecular dynamics for natural drug candidates
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Molecular Modeling"
DOI: 10.1007/s00894-020-04599-8
Abstract: A novel coronavirus (SARS-CoV-2) identified in Wuhan state of China in 2019 is the causative agent of deadly disease COVID-19. It has spread across the globe (more than 210 countries) within a short period. Coronaviruses… read more here.
Keywords: human ace2; drug candidates; protein sars; drug ... See more keywords
In-Silico Design of a Novel Tridecapeptide Targeting Spike Protein of SARS-CoV-2 Variants of Concern
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Peptide Research and Therapeutics"
DOI: 10.1007/s10989-021-10339-0
Abstract: Several mutations in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have increased the transmission and mortality rate of coronavirus disease-19 (COVID-19) across the globe. Although many vaccines have been developed, a large proportion of the… read more here.
Keywords: peptide; sars cov; spike protein; cov variants ... See more keywords
Ultrasound assisted synthesis of 3-alkynyl substituted 2-chloroquinoxaline derivatives: Their in silico assessment as potential ligands for N-protein of SARS-CoV-2
Sign Up to like & getrecommendations! Published in 2020 at "Tetrahedron Letters"
DOI: 10.1016/j.tetlet.2020.152336
Abstract: In view of recent global pandemic the 3-alkynyl substituted 2-chloroquinoxaline framework has been explored as a potential template for the design of molecules targeting COVID-19. Initial in silico studies of representative compounds to assess their… read more here.
Keywords: protein sars; alkynyl substituted; substituted chloroquinoxaline; sars cov ... See more keywords
Electrochemical Impedance-Based Biosensors for the Label-Free Detection of the Nucleocapsid Protein from SARS-CoV-2
Sign Up to like & getrecommendations! Published in 2022 at "ACS Sensors"
DOI: 10.1021/acssensors.2c00317
Abstract: Diagnosis of coronavirus disease (COVID-19) is important because of the emergence and global spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Real-time polymerase chain reaction (PCR) is widely used to diagnose COVID-19, but it… read more here.
Keywords: nucleocapsid protein; protein sars; detection; impedance ... See more keywords
A hybrid structure determination approach to investigate the druggability of the nucleocapsid protein of SARS-CoV-2
Sign Up to like & getrecommendations! Published in 2022 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkad195
Abstract: The ongoing pandemic caused by SARS-CoV-2 has called for concerted efforts to generate new insights into the biology of betacoronaviruses to inform drug screening and development. Here, we establish a workflow to determine the RNA… read more here.
Keywords: nucleocapsid protein; druggability nucleocapsid; protein sars; druggability ... See more keywords
Design of Potent Membrane Fusion Inhibitors against SARS-CoV-2, an Emerging Coronavirus with High Fusogenic Activity
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Virology"
DOI: 10.1128/jvi.00635-20
Abstract: The COVID-19 pandemic, caused by SARS-CoV-2, presents a serious global public health emergency in urgent need of prophylactic and therapeutic interventions. The S protein of coronaviruses mediates viral receptor binding and membrane fusion, thus being… read more here.
Keywords: fusion; activity; protein sars; membrane fusion ... See more keywords
DNA Aptamers Block the Receptor Binding Domain at the Spike Protein of SARS-CoV-2
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Molecular Biosciences"
DOI: 10.3389/fmolb.2021.713003
Abstract: DNA aptamers are versatile molecular species obtained by the folding of short single-stranded nucleotide sequences, with highly specific recognition capabilities against proteins. Here we test the ability of DNA aptamers to interact with the spike… read more here.
Keywords: protein sars; dna aptamers; spike protein; sars cov ... See more keywords
The Physical Basis for pH Sensitivity in Biomolecular Structure and Function, With Application to the Spike Protein of SARS-CoV-2
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Molecular Biosciences"
DOI: 10.3389/fmolb.2022.834011
Abstract: Since pH sensitivity has a fundamental role in biology, much effort has been committed to establishing physical models to rationalize and predict pH dependence from molecular structures. Two of the key challenges are to accurately… read more here.
Keywords: protein sars; sars cov; biology; spike protein ... See more keywords
New Monoclonal Antibodies Specific for Different Epitopes of the Spike Protein of SARS-CoV-2 and Its Major Variants: Additional Tools for a More Specific COVID-19 Diagnosis
Sign Up to like & getrecommendations! Published in 2023 at "Biomedicines"
DOI: 10.3390/biomedicines11020610
Abstract: The emergence of the new pathogen SARS-CoV-2 determined a rapid need for monoclonal antibodies (mAbs) to detect the virus in biological fluids as a rapid tool to identify infected individuals to be treated or quarantined.… read more here.
Keywords: major variants; protein sars; spike protein; monoclonal antibodies ... See more keywords