Mechanism‐Guided Design of Highly Efficient Protein Secretion and Lipid Conversion for Biomanufacturing and Biorefining
Sign Up to like & getrecommendations! Published in 2019 at "Advanced Science"
DOI: 10.1002/advs.201801980
Abstract: Abstract Bacterial protein secretion represents a significant challenge in biotechnology, which is essential for the cost‐effective production of therapeutics, enzymes, and other functional proteins. Here, it is demonstrated that proteomics‐guided engineering of transcription, translation, secretion,… read more here.
Keywords: secretion; secretion lipid; protein secretion; biomanufacturing biorefining ... See more keywords
Ano6 disruption impairs acinar cell regulatory volume decrease and protein secretion in murine submandibular salivary glands
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.29697
Abstract: The widely expressed Anoctamin 6 (Ano6) supports different Ca2+‐dependent functions, but little is known about its role in salivary glands. Mouse submandibular gland (SMG) acinar cells exhibited a robust regulatory volume decrease (RVD) following cell… read more here.
Keywords: ano6 disruption; secretion; volume; protein secretion ... See more keywords
Combining Whispering-Gallery Mode Optical Biosensors with Microfluidics for Real-Time Detection of Protein Secretion from Living Cells in Complex Media.
Sign Up to like & getrecommendations! Published in 2018 at "Small"
DOI: 10.1002/smll.201703705
Abstract: The noninvasive monitoring of protein secretion of cells responding to drug treatment is an effective and essential tool in latest drug development and for cytotoxicity assays. In this work, a surface functionalization method is demonstrated… read more here.
Keywords: detection; detection protein; real time; protein secretion ... See more keywords
An Overview of Protein Secretion in Yeast and Animal Cells.
Sign Up to like & getrecommendations! Published in 2017 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-7262-3_1
Abstract: Protein secretion mediated by the secretory transport pathway is an important cellular process in eukaryotic cells. In the conventional secretory transport pathway, newly synthesized proteins pass through several endomembrane compartments en route to their specific… read more here.
Keywords: animal cells; transport; secretory transport; protein secretion ... See more keywords
Challenges in Developing Protein Secretion Assays at a Single-Cell Level.
Sign Up to like & getrecommendations! Published in 2018 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-8567-8_1
Abstract: In addition to direct physical interactions between/among cells, the secretion of humoral factors from living cells is a critical process for cell-cell communications. A well-known extracellular signaling event is mediated by immune cell cytokines/chemokines. Because… read more here.
Keywords: secretion assays; protein secretion; biology; sociology ... See more keywords
Roads and hubs of unconventional protein secretion.
Sign Up to like & getrecommendations! Published in 2022 at "Current opinion in cell biology"
DOI: 10.1016/j.ceb.2022.02.006
Abstract: In eukaryotes, there is now compelling evidence that in addition to the conventional endoplasmic reticulum-Golgi secretory pathway, there are additional routes for the export of cytoplasmic proteins with a critical role in numerous physio-pathological conditions.… read more here.
Keywords: hubs unconventional; roads hubs; protein secretion; unconventional protein ... See more keywords
Loss of Cln3 impacts protein secretion in the social amoeba Dictyostelium.
Sign Up to like & getrecommendations! Published in 2017 at "Cellular signalling"
DOI: 10.1016/j.cellsig.2017.03.022
Abstract: Neuronal ceroid lipofuscinosis (NCL), also referred to as Batten disease, is the most common form of childhood neurodegeneration. Mutations in CLN3 cause the most prevalent subtype of the disease, which manifests during early childhood and… read more here.
Keywords: secretion; loss cln3; protein secretion; cln3 ... See more keywords
Unconventional mechanisms of eukaryotic protein secretion
Sign Up to like & getrecommendations! Published in 2018 at "Current Biology"
DOI: 10.1016/j.cub.2017.11.074
Abstract: A big surprise in the molecular cell biology of eukaryotes has been the discovery of pathways of protein secretion that are not linked to the endoplasmic reticulum (ER) and the Golgi apparatus. Various kinds of… read more here.
Keywords: unconventional mechanisms; secretion; protein secretion; biology ... See more keywords
Autophagy and protein secretion.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of molecular biology"
DOI: 10.1016/j.jmb.2020.01.015
Abstract: Autophagy - conventional for macroautophagy - is a major recycling strategy that ensures cellular homeostasis through the selective engulfment of cytoplasmic supramolecular cargos in double membrane vesicles and their rapid dispatch to the lysosome for… read more here.
Keywords: autophagy protein; secretion; secretory; protein secretion ... See more keywords
Contact-Dependent Interbacterial Antagonism Mediated by Protein Secretion Machines.
Sign Up to like & getrecommendations! Published in 2020 at "Trends in microbiology"
DOI: 10.1016/j.tim.2020.01.003
Abstract: To establish and maintain an ecological niche, bacteria employ a wide range of pathways to inhibit the growth of their microbial competitors. Some of these pathways, such as those that produce antibiotics or bacteriocins, exert… read more here.
Keywords: contact dependent; protein secretion; interbacterial antagonism; dependent interbacterial ... See more keywords
The Evolution of Protein Secretion Systems by Co-option and Tinkering of Cellular Machineries.
Sign Up to like & getrecommendations! Published in 2020 at "Trends in microbiology"
DOI: 10.1016/j.tim.2020.01.005
Abstract: Protein secretion is important for many biotic and abiotic interactions. The evolution of protein secretion systems of bacteria, and related nanomachines, occurred by the co-option of machineries for motility, conjugation, injection, or adhesion. Some of… read more here.
Keywords: systems option; secretion; secretion systems; protein secretion ... See more keywords