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Published in 2019 at "Trends in biochemical sciences"
DOI: 10.1016/j.tibs.2019.09.005
Abstract: Proteomic analysis can be a critical bottleneck in cellular characterization. The current paradigm relies primarily on mass spectrometry of peptides and affinity reagents (i.e., antibodies), both of which require a priori knowledge of the sample.…
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Keywords:
protein;
generation protein;
strategies development;
protein sequencing ... See more keywords
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Published in 2022 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.1c03718
Abstract: Accurate full-length sequencing of a purified unknown protein is still challenging nowadays due to the error-prone mass-spectrometry (MS)-based methods. De novo identified peptide sequence largely contain errors, undermining the accuracy of assembly. Bias on the…
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Keywords:
full length;
length protein;
accuracy;
protein sequencing ... See more keywords
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Published in 2022 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.2c13405
Abstract: Protein sequencing has rapidly changed the landscape of healthcare and life science by accelerating the growth of diagnostics and personalized medicines for a variety of fatal diseases. Next-generation nanopore/nanoslit sequencing is promising to achieve single-molecule…
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Keywords:
protein sequencing;
transmission function;
prediction;
prediction transmission ... See more keywords
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Published in 2019 at "Nature Communications"
DOI: 10.1038/s41467-019-13307-x
Abstract: Many complex processes, from protein folding to neuronal network dynamics, can be described as stochastic exploration of a high-dimensional energy landscape. Although efficient algorithms for cluster detection in high-dimensional spaces have been developed over the…
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Keywords:
high dimensional;
network;
learning dynamical;
time ... See more keywords
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Published in 2023 at "IET Nanobiotechnology"
DOI: 10.1049/nbt2.12124
Abstract: Abstract As biological macromolecules, proteins are involved in important cellular functions ranging from DNA replication and biosynthesis to metabolic signalling and environmental sensing. Protein sequencing can help understand the relationship between protein function and structure,…
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Keywords:
protein sequencing;
computer simulations;
detection;
nanopore sensors ... See more keywords