Cohesin-protein Shugoshin-1 controls cardiac automaticity via HCN4 pacemaker channel
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DOI: 10.1038/s41467-021-22737-5
Abstract: Endogenous cardiac pacemaker function regulates the rate and rhythm of cardiac contraction. The mutation p.Lys23Glu in the cohesin protein Shugoshin-1 causes severe heart arrhythmias due to sinoatrial node dysfunction and a debilitating gastrointestinal motility disorder,… read more here.
Keywords: pacemaker; channel; protein shugoshin; cohesin protein ... See more keywords