Hepatic Regulator of G protein Signaling 5 Ameliorates NAFLD by Suppressing TAK1-JNK/p38 Signaling.
Sign Up to like & getrecommendations! Published in 2020 at "Hepatology"
DOI: 10.1002/hep.31242
Abstract: BACKGROUND & AIMS Nonalcoholic fatty liver disease (NAFLD) is the most prevalent chronic liver disease, that has no specific pharmacological treatments partially due to the unclear pathophysiological mechanisms. Regulators of G protein signaling (RGS) proteins… read more here.
Keywords: protein; jnk p38; protein signaling; tak1 ... See more keywords
Elevated expression of sepiapterin reductase, regulator of G protein signaling 1, hypothetical protein CXorf58 homolog, and zinc finger and BTB domain-containing protein 21 isoform X2 is associated with progression of hepatocellular carcinoma.
Sign Up to like & getrecommendations! Published in 2021 at "Protoplasma"
DOI: 10.1007/s00709-021-01632-2
Abstract: Hepatocellular carcinoma (HCC) is one of the most common cancers associated with high mortality rate. Understanding of events leading to HCC pathophysiology is essential for its better management. We earlier reported development of a novel… read more here.
Keywords: protein; regulator protein; hepatocellular carcinoma; sepiapterin reductase ... See more keywords
G Protein Signaling in Plants: Characterization of Alpha and Gamma Subunits
Sign Up to like & getrecommendations! Published in 2017 at "Biophysical Journal"
DOI: 10.1016/j.bpj.2016.11.1052
Abstract: In plants heterotrimeric complexes of G proteins (consisting of alpha, beta, and gamma subunits) regulate several signaling pathways including seed germination, seedling development, organ shape and size determination. The alpha subunit has GTP binding and… read more here.
Keywords: gamma subunits; subunits protein; protein signaling; alpha subunit ... See more keywords
Regulator of G protein signaling 10: Structure, expression and functions in cellular physiology and diseases.
Sign Up to like & getrecommendations! Published in 2020 at "Cellular signalling"
DOI: 10.1016/j.cellsig.2020.109765
Abstract: Regulator of G protein signaling 10 (RGS10) belongs to the superfamily of RGS proteins, defined by the presence of a conserved RGS domain that canonically binds and deactivates heterotrimeric G-proteins. RGS proteins act as GTPase… read more here.
Keywords: regulator protein; protein signaling; physiology; expression ... See more keywords
VEGFR‐3 signaling is regulated by a G‐protein activator, activator of G‐protein signaling 8, in lymphatic endothelial cells
Sign Up to like & getrecommendations! Published in 2018 at "Experimental Cell Research"
DOI: 10.1016/j.yexcr.2018.04.007
Abstract: ABSTRACT Vascular endothelial growth factor C (VEGFC) and its cognate receptor VEGFR‐3 play a key role in lymphangiogenesis. We previously reported that an ischemia‐inducible G&bgr;&ggr; signal regulator, activator of G‐protein signaling 8 (AGS8), regulated the… read more here.
Keywords: activator; protein signaling; endothelial cells; lymphatic endothelial ... See more keywords
Regulation of heterotrimeric G-protein signaling by NDPK/NME proteins and caveolins: an update
Sign Up to like & getrecommendations! Published in 2018 at "Laboratory Investigation"
DOI: 10.1038/labinvest.2017.103
Abstract: Heterotrimeric G proteins are pivotal mediators of cellular signal transduction in eukaryotic cells and abnormal G-protein signaling plays an important role in numerous diseases. During the last two decades it has become evident that the… read more here.
Keywords: protein; regulation heterotrimeric; protein signaling; heterotrimeric proteins ... See more keywords
Interacting partners of Brassica juncea regulator of G-protein signaling protein suggest its role in cell wall metabolism and cellular signaling
Sign Up to like & getrecommendations! Published in 2022 at "Bioscience Reports"
DOI: 10.1042/bsr20220302
Abstract: Abstract Heterotrimeric G-proteins interact with various upstream and downstream effectors to regulate various aspects of plant growth and development. G-protein effectors have been recently reported in Arabidopsis thaliana; however, less information is available from polyploid… read more here.
Keywords: cell; cell wall; regulator protein; brassica juncea ... See more keywords
Small-molecule targeting of GPCR-independent noncanonical G-protein signaling in cancer.
Sign Up to like & getrecommendations! Published in 2023 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2213140120
Abstract: Activation of heterotrimeric G-proteins (Gαβγ) by G-protein-coupled receptors (GPCRs) is a quintessential mechanism of cell signaling widely targeted by clinically approved drugs. However, it has become evident that heterotrimeric G-proteins can also be activated via… read more here.
Keywords: small molecule; gpcr independent; noncanonical protein; protein signaling ... See more keywords
Functional analysis of seven regulators of G protein signaling (RGSs) in the nematode-trapping fungus Arthrobotrys oligospora
Sign Up to like & getrecommendations! Published in 2021 at "Virulence"
DOI: 10.1080/21505594.2021.1948667
Abstract: Abstract Regulators of G protein signaling (RGSs) are proteins that negatively regulate G protein signal transduction. In this study, seven putative RGSs were characterized in the nematode-trapping (NT) fungus, Arthrobotrys oligospora. Deleting Rgs genes significantly… read more here.
Keywords: signaling rgss; protein signaling; nematode trapping; regulators protein ... See more keywords
Development of Full Sweet, Umami, and Bitter Taste Responsiveness Requires Regulator of G protein Signaling-21 (RGS21)
Sign Up to like & getrecommendations! Published in 2018 at "Chemical Senses"
DOI: 10.1093/chemse/bjy024
Abstract: The mammalian tastes of sweet, umami, and bitter are initiated by activation of G protein-coupled receptors (GPCRs) of the T1R and T2R families on taste receptor cells. GPCRs signal via nucleotide exchange and hydrolysis, the… read more here.
Keywords: taste; sweet umami; protein signaling; rgs21 ... See more keywords
Ric8 acts as a regulator of G-protein signaling required for nematode-trapping lifecycle of Arthrobotrys oligospora.
Sign Up to like & getrecommendations! Published in 2021 at "Environmental microbiology"
DOI: 10.1111/1462-2920.15735
Abstract: Resistance to inhibitors of cholinesterase 8 (Ric8) is a conserved guanine nucleotide exchange factor that is involved in the regulation of G-protein signaling in filamentous fungi. Here, we characterized an orthologous Ric8 (AoRic8) in Arthrobotrys… read more here.
Keywords: ric8 acts; regulator protein; protein signaling; acts regulator ... See more keywords