Prediction and characterization of the stability enhancing effect of the Cherry-Tag™ in highly concentrated protein solutions by complex rheological measurements and MD simulations.
Sign Up to like & getrecommendations! Published in 2017 at "International journal of pharmaceutics"
DOI: 10.1016/j.ijpharm.2017.08.068
Abstract: Solution stability attributes are one of the key parameters within the production and launching phase of new biopharmaceuticals. Instabilities of active biological compounds can reduce the yield of biopharmaceutical productions, and may induce undesired reactions… read more here.
Keywords: cherry tag; tag highly; concentrated protein; protein solutions ... See more keywords
Crystallization of Lactose-Protein Solutions in the Presence of Flavonoids.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.1c05315
Abstract: Lactose is commonly crystallized in the presence of whey proteins, forming co-crystals of lactose and proteins. This work hypothesized that flavonoids such as rutin or epigallocatechin-3-gallate (EGCG) could be incorporated into the lactose and protein… read more here.
Keywords: lactose protein; protein solutions; solutions presence; crystallization lactose ... See more keywords
Potential and limits of a colloid approach to protein solutions.
Sign Up to like & getrecommendations! Published in 2019 at "Soft matter"
DOI: 10.1039/c9sm01953g
Abstract: Looking at globular proteins with the eyes of a colloid scientist has a long tradition, in fact a significant part of the early colloid literature was focused on protein solutions. However, it has also been… read more here.
Keywords: colloid science; colloid approach; protein solutions; colloid ... See more keywords
Dynamic cluster formation determines viscosity and diffusion in dense protein solutions
Sign Up to like & getrecommendations! Published in 2019 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.1817564116
Abstract: Significance For living cells to function, proteins must efficiently navigate the densely packed cytosol. Protein diffusion is slowed down by high viscosity and can come to a complete halt because of nonspecific binding and aggregation.… read more here.
Keywords: protein; viscosity; concentrated protein; protein solutions ... See more keywords
Computational models for studying physical instabilities in high concentration biotherapeutic formulations
Sign Up to like & getrecommendations! Published in 2022 at "mAbs"
DOI: 10.1080/19420862.2022.2044744
Abstract: ABSTRACT Computational prediction of the behavior of concentrated protein solutions is particularly advantageous in early development stages of biotherapeutics when material availability is limited and a large set of formulation conditions needs to be explored.… read more here.
Keywords: models studying; protein solutions; computational models; high concentration ... See more keywords
Calcium Chelation by Phosphate Ions and Its Influence on Fouling Mechanisms of Whey Protein Solutions in a Plate Heat Exchanger
Sign Up to like & getrecommendations! Published in 2021 at "Foods"
DOI: 10.3390/foods10020259
Abstract: Fouling of plate heat exchangers (PHEs) is a recurring problem when pasteurizing whey protein solutions. As Ca2+ is involved in denaturation/aggregation mechanisms of whey proteins, the use of calcium chelators seems to be a way… read more here.
Keywords: protein solutions; mechanisms whey; plate heat; whey protein ... See more keywords
Data Collection for Dilute Protein Solutions via a Neutron Backscattering Spectrometer
Sign Up to like & getrecommendations! Published in 2022 at "Life"
DOI: 10.3390/life12050675
Abstract: Understanding protein functions requires not only static but also dynamic structural information. Incoherent quasi-elastic neutron scattering (QENS), which utilizes the highly incoherent scattering ability of hydrogen, is a powerful technique for revealing the dynamics of… read more here.
Keywords: cell; neutron backscattering; dilute protein; protein solutions ... See more keywords