Direct Imaging of Protein‐Specific Methylation in Mammalian Cells
Sign Up to like & getrecommendations! Published in 2019 at "ChemBioChem"
DOI: 10.1002/cbic.201800787
Abstract: Abundant post‐translational modification through methylation alters the function, stability, and/or localization of a protein. Malfunctions in post‐translational modification are associated with severe diseases. To unravel protein methylation sites and their biological functions, chemical methylation reporters… read more here.
Keywords: protein; imaging protein; methylation; specific methylation ... See more keywords
Recent Advances in Protein‐Specific Glycan Imaging and Editing
Sign Up to like & getrecommendations! Published in 2023 at "ChemBioChem"
DOI: 10.1002/cbic.202200778
Abstract: Glycosylation in live cell and animal modulate a constellation of biological functions. The advent of Chemical Biology has revolutionized the analysis and tailoring of glycans, by introducing myriads of glycan engineering methods. However, the ideal… read more here.
Keywords: protein specific; specific glycan; imaging editing; glycan imaging ... See more keywords
Protein-Specific Analysis of Invertebrate Glycoproteins.
Sign Up to like & getrecommendations! Published in 2019 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-8814-3_24
Abstract: N-Glycans are posttranslational modifications of proteins attached to the amide side chains of asparagine residues, with possible heterogeneity due to different structures being possible at the same glycosylation site. In contrast to the mammalian systems,… read more here.
Keywords: analysis invertebrate; analysis; protein specific; specific analysis ... See more keywords
Quantifying Protein-Specific N-glycome Profiles by Focused Protein- and Immunoprecipitation-Glycomics.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of proteome research"
DOI: 10.1021/acs.jproteome.9b00232
Abstract: Serum N-glycans have been reported to be potential diagnostic and therapeutic biomarkers for many diseases and conditions, such as inflammation, fibrosis, and cancer progression. We previously described a method for glycomic analysis of gel-separated serum… read more here.
Keywords: specific glycome; glycome profiles; quantifying protein; immunoprecipitation glycomics ... See more keywords
Rational Design of Protein-Specific Folding Modifiers.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.1c09611
Abstract: Protein-folding can go wrong in vivo and in vitro, with significant consequences for the living organism and the pharmaceutical industry, respectively. Here we propose a design principle for small-peptide-based protein-specific folding modifiers. The principle is… read more here.
Keywords: protein; specific folding; protein specific; rational design ... See more keywords
Drosophila FIT is a protein-specific satiety hormone essential for feeding control
Sign Up to like & getrecommendations! Published in 2017 at "Nature Communications"
DOI: 10.1038/ncomms14161
Abstract: Protein homeostasis is critical for health and lifespan of animals. However, the mechanisms for controlling protein feeding remain poorly understood. Here we report that in Drosophila, protein intake-induced feeding inhibition (PIFI) is specific to protein-containing… read more here.
Keywords: protein; feeding; satiety hormone; specific satiety ... See more keywords
Silver nanoparticle plasmonic enhanced förster resonance energy transfer (FRET) imaging of protein-specific sialylation on the cell surface.
Sign Up to like & getrecommendations! Published in 2017 at "Nanoscale"
DOI: 10.1039/c7nr01562c
Abstract: A large amount of proteins are post-translationally modified with a sialic acid terminal oligosaccharide, and sialylation directly affects the function of glycoproteins and adjusts relevant biological processes. Herein, we developed a method for imaging analysis… read more here.
Keywords: protein; plasmonic enhanced; protein specific; sialylation ... See more keywords
Functional genomics of OCTN2 variants informs protein-specific variant effect predictor for Carnitine Transporter Deficiency
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2210247119
Abstract: Significance Interpretation of missense variants in clinically important genes is a critical challenge. Loss-of-function (LOF) variants in SLC22A5 (OCTN2) cause Carnitine Transporter Deficiency (CTD), a rare but potentially lethal inborn error of metabolism. Motivated by… read more here.
Keywords: specific variant; protein specific; carnitine transporter; transporter deficiency ... See more keywords
The SHDRA syndrome-associated gene TMEM260 encodes a protein-specific O-mannosyltransferase.
Sign Up to like & getrecommendations! Published in 2023 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2302584120
Abstract: Mutations in the TMEM260 gene cause structural heart defects and renal anomalies syndrome, but the function of the encoded protein remains unknown. We previously reported wide occurrence of O-mannose glycans on extracellular immunoglobulin, plexin, transcription… read more here.
Keywords: ipt domains; protein specific; mannosyltransferase; gene ... See more keywords
Prior SARS-CoV-2 infection enhances and reshapes spike protein–specific memory induced by vaccination
Sign Up to like & getrecommendations! Published in 2023 at "Science Translational Medicine"
DOI: 10.1126/scitranslmed.ade0550
Abstract: The diversity of vaccination modalities and infection history are both variables that have an impact on the immune memory of individuals vaccinated against SARS-CoV-2. To gain more accurate knowledge of how these parameters imprint on… read more here.
Keywords: vaccination; infection; protein specific; spike protein ... See more keywords
Evaluation of infection with N protein-specific Immunoglobulin M and G in naturally occurring distemper in dogs
Sign Up to like & getrecommendations! Published in 2020 at "Veterinarni Medicina"
DOI: 10.17221/31/2019-vetmed
Abstract: In dogs, canine distemper has a worldwide distribution with high morbidity/mortality, despite the widespread usage of vaccines and has no specific treatment. In susceptible animals with the canine distemper virus, respiratory, gastrointestinal and nervous system… read more here.
Keywords: infection; canine distemper; protein specific; evaluation ... See more keywords