Structural basis of protein substrate processing by human mitochondrial high-temperature requirement A2 protease
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DOI: 10.1073/pnas.2203172119
Abstract: Significance Protein aggregates are often toxic, leading to impaired cellular activities and disease. The human HtrA2 trimeric enzyme cleaves such aggregates, and mutations in HtrA2 are causative for various neurodegenerative disorders, such as Parkinson’s disease… read more here.
Keywords: htra2; structural basis; protein substrate; basis protein ... See more keywords