Kingdom Chromista and its eight phyla: a new synthesis emphasising periplastid protein targeting, cytoskeletal and periplastid evolution, and ancient divergences
Sign Up to like & getrecommendations! Published in 2017 at "Protoplasma"
DOI: 10.1007/s00709-017-1147-3
Abstract: In 1981 I established kingdom Chromista, distinguished from Plantae because of its more complex chloroplast-associated membrane topology and rigid tubular multipartite ciliary hairs. Plantae originated by converting a cyanobacterium to chloroplasts with Toc/Tic translocons; most… read more here.
Keywords: protein; evolution; periplastid; protein targeting ... See more keywords
Protein Targeting Chimeric Molecules Specific for Bromodomain and Extra-terminal Motif Family Proteins are Active Against Pre-Clinical Models of Multiple Myeloma
Sign Up to like & getrecommendations! Published in 2018 at "Leukemia"
DOI: 10.1038/s41375-018-0044-x
Abstract: Bromodomain and extraterminal (BET) domain containing protein (BRD)-4 modulates the expression of oncogenes such as c-myc, and is a promising therapeutic target in diverse cancer types. We performed pre-clinical studies in myeloma models with bi-functional… read more here.
Keywords: protein; targeting chimeric; protein targeting; pre clinical ... See more keywords
Loss of PROTEIN TARGETING TO STARCH 2 has variable effects on starch synthesis across organs and species
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Experimental Botany"
DOI: 10.1093/jxb/erac268
Abstract: Loss of PTST2, a protein involved in starch granule initiation, had highly variable effects between three grass species on carbohydrate metabolism and physiology of leaves and granule morphology of seeds. read more here.
Keywords: protein targeting; variable effects; loss protein; loss ... See more keywords
Defining the physiological role of SRP in protein-targeting efficiency and specificity
Sign Up to like & getrecommendations! Published in 2018 at "Science"
DOI: 10.1126/science.aar3607
Abstract: When do you really need SRP? Proteins destined for the cell exterior are recruited during synthesis to the surface of the endoplasmic reticulum (ER) by the signal recognition particle (SRP). The classic view suggests that… read more here.
Keywords: srp; protein targeting; role srp; physiological role ... See more keywords
Bcl-2 Protein Targeting by the p53/p21 Complex-Response.
Sign Up to like & getrecommendations! Published in 2018 at "Cancer research"
DOI: 10.1158/0008-5472.can-17-3919
Abstract: We thank Hernandez Borrero and colleagues for their comments ([1][1]) on our article ([2][2]), especially their consideration of novel paradigm-shifting aspects. As they requested, we have presented coimmunoprecipitation data showing endogenous p53–p21 protein interaction in… read more here.
Keywords: p53 p21; bcl protein; protein targeting; p53 ... See more keywords
M7824 (MSB0011359C), a bifunctional fusion protein targeting PD-L1 and TGF-β, in Asian patients with pretreated recurrent or refractory gastric cancer: Preliminary results from a phase I trial.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2018.36.4_suppl.100
Abstract: 100Background: Inhibiting the transforming growth factor β (TGF-β) pathway, which plays a key role in tumor immunosuppression, may enhance the response to programmed death 1/programmed death ligand... read more here.
Keywords: m7824 msb0011359c; protein targeting; targeting tgf; msb0011359c bifunctional ... See more keywords
A photosensitizing fusion protein with targeting capabilities
Sign Up to like & getrecommendations! Published in 2022 at "Biomolecular Concepts"
DOI: 10.1515/bmc-2022-0014
Abstract: Abstract The photodynamic treatment for antimicrobial applications or anticancer therapy relies on reactive oxygen species generated by photosensitizing molecules after absorption of visible or near-infrared light. If the photosensitizing molecule is in close vicinity of… read more here.
Keywords: photosensitizing fusion; targeting capabilities; fusion protein; protein targeting ... See more keywords
Compensating Complete Loss of Signal Recognition Particle During Co-translational Protein Targeting by the Translation Speed and Accuracy
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2021.690286
Abstract: Signal recognition particle (SRP) is critical for delivering co-translational proteins to the bacterial inner membrane. Previously, we identified SRP suppressors in Escherichia coli that inhibit translation initiation and elongation, which provided insights into the mechanism… read more here.
Keywords: signal recognition; protein targeting; srp; translation ... See more keywords
Protein Targeting Into the Thylakoid Membrane Through Different Pathways
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Physiology"
DOI: 10.3389/fphys.2021.802057
Abstract: In higher plants, chloroplasts are essential semi-autonomous organelles with complex compartments. As part of these sub-organellar compartments, the sheet-like thylakoid membranes contain abundant light-absorbing chlorophylls bound to the light-harvesting proteins and to some of the… read more here.
Keywords: membrane different; different pathways; protein targeting; thylakoid membrane ... See more keywords
The Molecular Biodiversity of Protein Targeting and Protein Transport Related to the Endoplasmic Reticulum
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DOI: 10.3390/ijms23010143
Abstract: Looking at the variety of the thousands of different polypeptides that have been focused on in the research on the endoplasmic reticulum from the last five decades taught us one humble lesson: no one size… read more here.
Keywords: protein targeting; biodiversity protein; molecular biodiversity; reticulum ... See more keywords
Fidelity of Cotranslational Protein Targeting to the Endoplasmic Reticulum
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DOI: 10.3390/ijms23010281
Abstract: Fidelity of protein targeting is essential for the proper biogenesis and functioning of organelles. Unlike replication, transcription and translation processes, in which multiple mechanisms to recognize and reject noncognate substrates are established in energetic and… read more here.
Keywords: protein; protein localization; fidelity cotranslational; protein targeting ... See more keywords