TLR9‐Driven S‐Palmitoylation in Dendritic Cells Reveals Immune and Metabolic Protein Targets
Sign Up to like & getrecommendations! Published in 2025 at "European Journal of Immunology"
DOI: 10.1002/eji.70039
Abstract: Dendritic cells (DCs) rely on Toll‐like receptor 9 (TLR9) to detect unmethylated CpG motifs in microbial DNA, triggering essential immune responses. While the downstream signaling pathways of TLR9 activation are well characterized, their impact on… read more here.
Keywords: immune metabolic; protein targets; palmitoylation; dendritic cells ... See more keywords
Homology Modeling of Protein Targets with MODELLER.
Sign Up to like & getrecommendations! Published in 2019 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-9752-7_15
Abstract: Homology modeling is a computational approach to generate three-dimensional structures of protein targets when experimental data about similar proteins are available. Although experimental methods such as X-ray crystallography and nuclear magnetic resonance spectroscopy successfully solved… read more here.
Keywords: modeling protein; targets modeller; homology modeling; spectroscopy ... See more keywords
A Common Molecular Switch for H2S to Regulate Multiple Protein Targets.
Sign Up to like & getrecommendations! Published in 2021 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-981-16-0991-6_1
Abstract: Hydrogen sulfide, a small molecule, produced by endogenous enzymes, such as CTH, CBS, and MPST using L-cysteine as substrates, has been reported to have numerous protective effects. However, the key problem that the target of… read more here.
Keywords: common molecular; protein targets; switch h2s; molecular switch ... See more keywords
Discussion of the protein characterization techniques used in the identification of membrane protein targets corresponding to tumor cell aptamers
Sign Up to like & getrecommendations! Published in 2020 at "Chinese Chemical Letters"
DOI: 10.1016/j.cclet.2020.11.061
Abstract: Abstract Aptamer is an oligonucleotide chain with specific binding ability to protein and other targets, which is widely used in many fields. Because of its ability to screen the premise of unknown targets, it can… read more here.
Keywords: protein; characterization; tumor markers; protein targets ... See more keywords
Complex network theory for the identification and assessment of candidate protein targets
Sign Up to like & getrecommendations! Published in 2018 at "Computers in biology and medicine"
DOI: 10.1016/j.compbiomed.2018.04.015
Abstract: In this work we use complex network theory to provide a statistical model of the connectivity patterns of human proteins and their interaction partners. Our intention is to identify important proteins that may be predisposed… read more here.
Keywords: complex network; protein targets; network theory; target proteins ... See more keywords
Reactions of Arsenoplatin-1 with Protein Targets: A Combined Experimental and Theoretical Study
Sign Up to like & getrecommendations! Published in 2022 at "Inorganic Chemistry"
DOI: 10.1021/acs.inorgchem.1c03732
Abstract: Arsenoplatin-1 (AP-1) is a dual-action anticancer metallodrug with a promising pharmacological profile that features the simultaneous presence of a cisplatin-like center and an arsenite center. We investigated its interactions with proteins through a joint experimental… read more here.
Keywords: experimental theoretical; protein targets; targets combined; reactions arsenoplatin ... See more keywords
Concentration-Dependent Enrichment Identifies Primary Protein Targets of Multitarget Bioactive Molecules.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of proteome research"
DOI: 10.1021/acs.jproteome.2c00550
Abstract: Multitarget bioactive molecules (MBMs) are of increasing importance in drug discovery as they could produce high efficacy and a low chance of resistance. Several advanced approaches of quantitative proteomics were developed to accurately identify the… read more here.
Keywords: enrichment; protein targets; primary protein; low concentrations ... See more keywords
Selection of DNA-encoded Libraries to Protein Targets Within and On Living Cells.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.9b08085
Abstract: We report the selection of DNA-encoded small molecule libraries against protein targets within the cytosol and on the surface of live cells. The approach relies on generation of a covalent linkage of the DNA to… read more here.
Keywords: dna; targets within; dna encoded; protein targets ... See more keywords
De novo generation of multi-target compounds using deep generative chemistry
Sign Up to like & getrecommendations! Published in 2024 at "Nature Communications"
DOI: 10.1038/s41467-024-47120-y
Abstract: Polypharmacology drugs—compounds that inhibit multiple proteins—have many applications but are difficult to design. To address this challenge we have developed POLYGON, an approach to polypharmacology based on generative reinforcement learning. POLYGON embeds chemical space and… read more here.
Keywords: chemistry; compounds targeting; novo generation; protein targets ... See more keywords
Bioinformatic prediction, annotation and experimental validation of conserved microRNAs in Lactuca sativa Linn
Sign Up to like & getrecommendations! Published in 2025 at "Scientific Reports"
DOI: 10.1038/s41598-025-88689-8
Abstract: MicroRNAs (miRNAs) are non-coding RNAs that play crucial role in post-transcriptional gene regulation, with lengths ranging from 18 to 26 nucleotides (nt). These endogenously expressed molecules exhibit significant evolutionary conservation, a feature vital for identifying… read more here.
Keywords: sativa linn; conserved mirnas; protein targets; lactuca sativa ... See more keywords
A proteomics approach to identifying novel protein targets involved in erinacine A–mediated inhibition of colorectal cancer cells’ aggressiveness
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.13004
Abstract: Erinacine A, a major active component of a diterpenoid derivative isolated from Hericium erinaceus mycelium, has been demonstrated to exert anticancer effects. Herein, we present an investigation of the molecular mechanism of erinacine A induction… read more here.
Keywords: pi3k mtor; novel protein; erinacine; cancer cells ... See more keywords