Yeast surface display of full‐length human microtubule‐associated protein tau
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DOI: 10.1002/btpr.2920
Abstract: Microtubule‐associated protein tau is an intrinsically disordered, highly soluble protein found primarily in neurons. Under normal conditions, tau regulates the stability of axonal microtubules and intracellular vesicle transport. However, in patients of neurodegeneration such as… read more here.
Keywords: protein; associated protein; tau; microtubule associated ... See more keywords
Clinicopathologic heterogeneity in frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP‐17) due to microtubule‐associated protein tau (MAPT) p.P301L mutation, including a patient with globular glial tauopathy
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DOI: 10.1111/nan.12367
Abstract: The p.P301L mutation in microtubule‐associated protein tau (MAPT) is a common cause of frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP‐17). We compare clinicopathologic features of five unrelated and three related (brother, sister and… read more here.
Keywords: associated protein; microtubule associated; protein tau; tau mapt ... See more keywords
Proteasomal degradation of the intrinsically disordered protein tau at single-residue resolution
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DOI: 10.1126/sciadv.aba3916
Abstract: Dissecting the degradation of the Alzheimer’s disease–related protein Tau by the 20S proteasome at single-residue resolution. Intrinsically disordered proteins (IDPs) can be degraded in a ubiquitin-independent process by the 20S proteasome. Decline in 20S activity… read more here.
Keywords: single residue; degradation; residue resolution; protein tau ... See more keywords