Protein N-Terminal Acetylation: Structural Basis, Mechanism, Versatility, and Regulation.
Sign Up to like & getrecommendations! Published in 2020 at "Trends in biochemical sciences"
DOI: 10.1016/j.tibs.2020.08.005
Abstract: N-terminal acetylation (NTA) is one of the most widespread protein modifications, which occurs on most eukaryotic proteins, but is significantly less common on bacterial and archaea proteins. This modification is carried out by a family… read more here.
Keywords: protein terminal; acetylation; mechanism; terminal acetylation ... See more keywords
Asparaginyl Endopeptidase-Mediated Protein C-Terminal Hydrazinolysis for the Synthesis of Bioconjugates.
Sign Up to like & getrecommendations! Published in 2022 at "Bioconjugate chemistry"
DOI: 10.1021/acs.bioconjchem.1c00551
Abstract: Asparaginyl endopeptidases (AEPs) are cysteinyl enzymes naturally catalyzing the hydrolysis and transpeptidation reactions at Asx-Xaa bonds. These reactions go by a common acyl-enzyme thioester intermediate, which is either attacked by water (for a protease-AEP) or… read more here.
Keywords: endopeptidase mediated; protein terminal; terminal hydrazinolysis; mediated protein ... See more keywords
Protein C-Terminal Tyrosine Conjugation via Recyclable Immobilized BmTYR
Sign Up to like & getrecommendations! Published in 2022 at "ACS Omega"
DOI: 10.1021/acsomega.2c05794
Abstract: Protein modification plays an essential role in biological and pharmaceutical research. Due to the ordinary selectivity and inevitable damage to proteins of chemical synthetic methods, increased efforts were focused on biocatalysts which exhibited high regioselectivity… read more here.
Keywords: tyrosine conjugation; protein terminal; bmtyr; terminal tyrosine ... See more keywords
Relationship of uric acid, C-reactive protein, and N-terminal pro-B-type natriuretic peptide with acute cerebral infarction.
Sign Up to like & getrecommendations! Published in 2021 at "Revista da Associacao Medica Brasileira"
DOI: 10.1590/1806-9282.20210693
Abstract: OBJECTIVE The objective was to study the relationship of serum uric acid, C-reactive protein, and N-terminal pro-B-type natriuretic peptide levels with acute cerebral infarction. METHODS A total of 96 acute cerebral infarction patients were divided… read more here.
Keywords: terminal pro; infarction; reactive protein; acid reactive ... See more keywords
Improved Cell-Potent and Selective Peptidomimetic Inhibitors of Protein N-Terminal Methyltransferase 1
Sign Up to like & getrecommendations! Published in 2022 at "Molecules"
DOI: 10.3390/molecules27041381
Abstract: Protein N-terminal methyltransferase 1 (NTMT1) recognizes a unique N-terminal X-P-K/R motif (X represents any amino acid other than D/E) and transfers 1–3 methyl groups to the N-terminal region of its substrates. Guided by the co-crystal… read more here.
Keywords: protein terminal; cell potent; terminal methyltransferase; peptidomimetic inhibitors ... See more keywords