In vivo biodistribution study of TAT-L-Sco2 fusion protein, developed as protein therapeutic for mitochondrial disorders attributed to SCO2 mutations
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Genetics and Metabolism Reports"
DOI: 10.1016/j.ymgmr.2020.100683
Abstract: The rapid progress achieved in the development of many biopharmaceuticals had a tremendous impact on the therapy of many metabolic/genetic disorders. This type of fruitful approach, called protein replacement therapy (PRT), aimed to either replace… read more here.
Keywords: protein; biodistribution; protein therapeutic; sco2 fusion ... See more keywords
An IL-2 Protein Therapeutic for Cancer that Gains Function on the Spot.
Sign Up to like & getrecommendations! Published in 2022 at "Cancer immunology research"
DOI: 10.1158/2326-6066.cir-22-0186
Abstract: Recombinant human IL-2 (rhIL-2) is now rarely used to treat patients with cancer because it too often causes severe toxicities. In this issue, Nirschl and colleagues report the development and preclinical characterization of an engineered… read more here.
Keywords: cancer gains; protein therapeutic; function spot; therapeutic cancer ... See more keywords