Improving the Accuracy of Protein Thermostability Predictions for Single Point Mutations.
Sign Up to like & getrecommendations! Published in 2020 at "Biophysical journal"
DOI: 10.1016/j.bpj.2020.05.020
Abstract: Accurately predicting the protein thermostability changes upon single point mutations in silico is a challenge that has implications for understanding diseases as well as industrial applications of protein engineering. Free energy perturbation (FEP) has been applied… read more here.
Keywords: stability; point mutations; accuracy; protein thermostability ... See more keywords
CalFitter 2.0: Leveraging the power of singular value decomposition to analyse protein thermostability
Sign Up to like & getrecommendations! Published in 2022 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkac378
Abstract: Abstract The importance of the quantitative description of protein unfolding and aggregation for the rational design of stability or understanding the molecular basis of protein misfolding diseases is well established. Protein thermostability is typically assessed… read more here.
Keywords: calfitter; protein thermostability; value decomposition; singular value ... See more keywords
Testing and improving the performance of protein thermostability predictors for the engineering of cellulases.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of bioinformatics and computational biology"
DOI: 10.1142/s0219720023300010
Abstract: Thermostability of cellulases can be increased through amino acid substitutions and by protein engineering with predictors of protein thermostability. We have carried out a systematic analysis of the performance of 18 predictors for the engineering… read more here.
Keywords: protein thermostability; predictors engineering; thermostability; engineering cellulases ... See more keywords