Cln3‐mutations underlying juvenile neuronal ceroid lipofuscinosis cause significantly reduced levels of Palmitoyl‐protein thioesterases‐1 (Ppt1)‐protein and Ppt1‐enzyme activity in the lysosome
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Inherited Metabolic Disease"
DOI: 10.1002/jimd.12106
Abstract: Mutations in at least 13 different genes (called CLNs) underlie various forms of neuronal ceroid lipofuscinoses (NCLs), a group of the most common neurodegenerative lysosomal storage diseases. While inactivating mutations in the CLN1 gene, encoding… read more here.
Keywords: palmitoyl protein; neuronal ceroid; ceroid; cln3 mutations ... See more keywords
Combinatorial Optimization of Activity-Based Probes for Acyl Protein Thioesterases 1 and 2.
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DOI: 10.1021/acsmedchemlett.2c00174
Abstract: Acyl protein thioesterases hydrolyze fatty acid thioesters on cysteine residues of proteins. The two protein depalmitoylases APT1 and APT2 have a very high degree of similarity and show substantial overlap in substrate utility. Potent, selective,… read more here.
Keywords: based probes; activity based; acyl protein; protein thioesterases ... See more keywords
Development of an activity-based probe for acyl-protein thioesterases
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DOI: 10.1371/journal.pone.0190255
Abstract: Protein palmitoylation is a dynamic post-translational modification (PTM) important for cellular functions such as protein stability, trafficking, localization, and protein-protein interactions. S-palmitoylation occurs via the addition of palmitate to cysteine residues via a thioester linkage,… read more here.
Keywords: protein; probe; activity based; protein thioesterases ... See more keywords
Protein S-acyltransferases and acyl protein thioesterases, regulation executors of protein S-acylation in plants
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Plant Science"
DOI: 10.3389/fpls.2022.956231
Abstract: Protein S-acylation, also known as palmitoylation, is an important lipid post-translational modification of proteins in eukaryotes. S-acylation plays critical roles in a variety of protein functions involved in plant development and responses to abiotic and… read more here.
Keywords: protein acylation; acylation; acyl protein; protein thioesterases ... See more keywords